Auditory hallucinations activate language and verbal short-term memory, but not auditory, brain regions

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• dc.contributor.author Fuentes‑Claramonte, Paola
• dc.contributor.author Soler‑Vidal, Joan
• dc.contributor.author Salgado‑Pineda, Pilar
• dc.contributor.author García‑León, María Ángeles
• dc.contributor.author Ramiro, Nuria
• dc.contributor.author Santo‑Angles, Aniol
• dc.contributor.author Llanos Torres, María
• dc.contributor.author Tristany, Josep
• dc.contributor.author Guerrero-Pedraza, Amalia
• dc.contributor.author Munuera, Josep
• dc.contributor.author Sarró, Salvador
• dc.contributor.author Salvador, Raymond
• dc.contributor.author Hinzen, Wolfram
• dc.contributor.author McKenna, Peter J.
• dc.contributor.author Pomarol-Clotet, Edith
• dc.date.accessioned 2022-05-25T05:33:25Z
• dc.date.available 2022-05-25T05:33:25Z
• dc.date.issued 2021
• dc.description.abstract Auditory verbal hallucinations (AVH, ‘hearing voices’) are an important symptom of schizophrenia but their biological basis is not well understood. One longstanding approach proposes that they are perceptual in nature, specifcally that they refect spontaneous abnormal neuronal activity in the auditory cortex, perhaps with additional ‘top down’ cognitive infuences. Functional imaging studies employing the symptom capture technique—where activity when patients experience AVH is compared to times when they do not—have had mixed fndings as to whether the auditory cortex is activated. Here, using a novel variant of the symptom capture technique, we show that the experience of AVH does not induce auditory cortex activation, even while real speech does, something that efectively rules out all theories that propose a perceptual component to AVH. Instead, we fnd that the experience of AVH activates language regions and/or regions that are engaged during verbal shortterm memoryen
• dc.format.mimetype application/pdf
• dc.identifier.citation Fuentes‑Claramonte P, Soler‑Vidal J, Salgado‑Pineda P, García‑León MA, Ramiro N, Santo‑Angles A, Llanos Torres M, Tristany J, Guerrero‑Pedraza A, Munuera J, Sarró S, Salvador R, Hinzen W, McKenna PJ, Pomarol‑Clotet E. Auditory hallucinations activate language and verbal short-term memory, but not auditory, brain regions. Sci Rep. 2021;11:18890. DOI: 10.1038/s41598-021-98269-1
• dc.identifier.doi http://dx.doi.org/10.1038/s41598-021-98269-1
• dc.identifier.issn 2045-2322
• dc.identifier.uri http://hdl.handle.net/10230/53234
• dc.language.iso eng
• dc.publisher Nature Research
• dc.relation.ispartof Scientific Reports. 2021;11:18890
• dc.rights This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. © The Author(s) 2021
• dc.rights.accessRights info:eu-repo/semantics/openAccess
• dc.rights.uri http://creativecommons.org/licenses/by/4.0/
• dc.subject.other Esquizofrèniacat
• dc.subject.other Al·lucinacions acústiquescat
• dc.subject.other Memòria immediatacat
• dc.title Auditory hallucinations activate language and verbal short-term memory, but not auditory, brain regions
• dc.type info:eu-repo/semantics/article
• dc.type.version info:eu-repo/semantics/publishedVersion