Auditory hallucinations activate language and verbal short-term memory, but not auditory, brain regions

Fuentes‑Claramonte, Paola; Soler‑Vidal, Joan; Salgado‑Pineda, Pilar; García‑León, María Ángeles; Ramiro-Sousa, Nuria; Santo‑Angles, Aniol; Llanos Torres, María; Tristany, Josep; Guerrero-Pedraza, Amalia; Munuera, Josep; Sarró, Salvador; Salvador, Raymond; Hinzen, Wolfram; McKenna, Peter J.; Pomarol-Clotet, Edith

doi:http://dx.doi.org/10.1038/s41598-021-98269-1

Auditory hallucinations activate language and verbal short-term memory, but not auditory, brain regions

License

Citation

Fuentes‑Claramonte P, Soler‑Vidal J, Salgado‑Pineda P, García‑León MA, Ramiro N, Santo‑Angles A, Llanos Torres M, Tristany J, Guerrero‑Pedraza A, Munuera J, Sarró S, Salvador R, Hinzen W, McKenna PJ, Pomarol‑Clotet E. Auditory hallucinations activate language and verbal short-term memory, but not auditory, brain regions. Sci Rep. 2021;11:18890. DOI: 10.1038/s41598-021-98269-1

Abstract

Auditory verbal hallucinations (AVH, ‘hearing voices’) are an important symptom of schizophrenia but their biological basis is not well understood. One longstanding approach proposes that they are perceptual in nature, specifcally that they refect spontaneous abnormal neuronal activity in the auditory cortex, perhaps with additional ‘top down’ cognitive infuences. Functional imaging studies employing the symptom capture technique—where activity when patients experience AVH is compared to times when they do not—have had mixed fndings as to whether the auditory cortex is activated. Here, using a novel variant of the symptom capture technique, we show that the experience of AVH does not induce auditory cortex activation, even while real speech does, something that efectively rules out all theories that propose a perceptual component to AVH. Instead, we fnd that the experience of AVH activates language regions and/or regions that are engaged during verbal shortterm memory