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Welcome to the UPF Digital Repository

The institutional repository collects, disseminates and preserves, in digital form, the intellectual output that results from the academic and research activity of the UPF and also the scientific magazines and the institutional publications. Its purpose is to increase the impact of research done at the UPF and its intellectual memory.

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Regulation of T cell fates by the transcription factor NFAT5 in different microenvironments

Alberdi Ibarzabal, Maria, 1986- (Universitat Pompeu Fabra, 2015-07-24)

CD4+ T cells can adopt specific functional programs in response to changes in microenvironment variables, such as cytokine availability, cell-to-cell contacts and stress conditions. It has been described that the elevation ...
Clinical presentations and outcomes related to tuberculosis in children younger than 2 years of age in Catalonia

Soriano-Arandes, Antoni; López Segura, María Nuria; Caylà i Busqueras, Joan A. (Frontiers, 2019)

Introduction: Children younger than 2 years have an increased risk of complications associated with tuberculosis (TB) due to the immaturity of the innate and adaptive immune response. We aimed to identify TB clinical ...
A combined transcriptomic and genomic analysis identifies a gene signature associated with the response to anti-TNF therapy in rheumatoid arthritis

Aterido, Adrià; Cañete Crespillo, Juan de Dios; Tornero, Jesús; Blanco, Francisco; Fernández-Gutiérrez, Benjamín; Pérez-García, Carolina; Alperiz, Mercedes; Olivé, Alex; Corominas, Héctor; Martínez-Taboada, Víctor; González-Alvaro, Isidoro; Fernández-Nebro, Antonio; Erra, Alba; López Lasanta, María; López Corbeto, Mireia; Palau, Núria; Marsal, Sara; Julià, Antonio (Frontiers, 2019)

Background: Rheumatoid arthritis (RA) is the most frequent autoimmune disease involving the joints. Although anti-TNF therapies have proven effective in the management of RA, approximately one third of patients do not show ...
Identification of genetic modifiers of penetrance in human inherited disease

Puigdevall Costa, Pau, 1991- (Universitat Pompeu Fabra, 2019-01-17)

Understanding the molecular basis of human inherited disease is a challenging task due to the complexity of mapping the genotype to the phenotype. The study of diseases running in families has shown that the inheritance ...
Non-vertical genomics in fungal evolution

Naranjo Ortiz, Miguel Ángel, 1989- (Universitat Pompeu Fabra, 2019-01-18)

Non-vertical genomic events, which include horizontal gene transfer (HGT) and hybridization, are widely studied evolutionary processes in certain groups. HGT is particularly well known for prokaryotic organisms, while ...