Recerca: articles, congressos, llibres
Documents de recerca de la UPF, en accés obert, com ara articles de revista, llibres, comunicacions, ponències o posters a jornades i congressos, etc. Aquests i materials d'altres institucions estan disponibles a Recercat (Dipòsit de la Recerca de Catalunya).
URI permanent per a aquesta comunitat http://hdl.handle.net/10230/5542
Navigate
Browse
Recent Submissions
Item type: Item , Allergic contact dermatitis in adults with and without atopic dermatitis: Evaluation of the Spanish Contact Dermatitis Registry (REIDAC)(Wiley, 2024) Chicharro, Pablo; Giménez Arnau, Anna Maria; Sánchez-Pérez, JavierBackground: Atopic dermatitis (AD) and allergic contact dermatitis (ACD) are inflammatory skin conditions whose association is not clearly defined. Objectives: To identify differences in ACD profile between patients with and without AD among those referred for patch testing. Additionally, to determine the prevalence of sensitisation to standard Spanish contact allergens in both groups. Methods: We analysed two groups (AD and non-AD) within the Spanish Registry of Research in Contact Dermatitis and Cutaneous Allergy (REIDAC). Contact allergy, clinical relevance and epidemiological data were compared between them. Results: A total of 5055 patients were included. Among them, 23% (1168) had a history or final diagnosis of AD. At least one positive reaction was seen in 468 (40%) of AD patients and 1864 (48%) of non-AD patients. In both groups, the most common positive reactions were to nickel sulphate, methylchloroisothiazolinone/methylisothiazolinone and cobalt chloride. Age-adjusted OR for sensitisation to nickel sulphate was 0.72 (95% CI: 0.61-0.86), indicating a decreased likelihood of sensitisation in AD patients compared to non-AD individuals. Conclusions: We did not find an increased presence of ACD in patients with AD referred for patch testing, exhibiting similar profiles to non-AD population, except for a negative relationship between AD and sensitisation to nickel sulphate.Item type: Item , Serum vitamin B12 concentration is associated with improved memory in older individuals with higher adherence to the Mediterranean diet(Elsevier, 2023) Domínguez-López, Inés; Casas, Rosa; Chiva-Blanch, Gemma; Martínez-González, Miguel Ángel, 1957-; Fitó Colomer, Montserrat; Ros, Emilio; Lamuela Raventós, Rosa Ma.; Estruch, RamónBackground & aims: Vitamin B12 plays a crucial role in cognition, but its effect might be regulated by the presence of other micronutrients, such as folate. The aim was to evaluate the effects of vitamin B12 on cognitive performance according to adherence to the Mediterranean diet, and whether the Mediterranean diet also results in increased folate or vitamin B12 levels. Methods: This is a cohort study nested in a randomized controlled clinical trial performed in Hospital Clinic in Barcelona, Spain. A total of 170 participants of the PREDIMED trial (Barcelona - Hospital Clinic site) aged 55-80 years at high cardiovascular risk were included. Adherence to the Mediterranean diet was assessed using a validated 14-item questionnaire, memory function was evaluated with a battery of neuropsychological tests and serum vitamin B12 and folate were determined using an automated electrochemiluminiscence immunoassay system. Results: In the multivariable adjusted linear regression model, serum vitamin B12 concentration presented a significant correlation with memory function (r2 = 0.57; P = 0.028) in participants with high adherence to the Mediterranean diet whereas the correlation was weak and inverse for those who presented a low adherence to the Mediterranean diet (r2 = 0.37, P = 0.731). Mediterranean diet adherence showed a positive association with serum folate, but not with serum vitamin B12. Conclusions: In an older Mediterranean population at high cardiovascular risk, changes in serum vitamin B12 correlate with better memory function only in the context of a high adherence to the Mediterranean pattern, suggesting that the effects of vitamin B12 goes further than a mere nutritional requirement. Institutional review board statement: The study was conducted according to the guidelines of the Declaration of Helsinki and was approved by the Institutional Review Board of the 11 participating centres. The study was registered with the International Standard Randomized Controlled Trial Number (ISRCTN) 35739639 (https://www.isrctn.com/ISRCTN35739639).Item type: Item , Frailty and sarcopenia metabolomic signatures in kidney transplant candidates: the FRAILMar study(Oxford University Press, 2025) Madrid-Gambin, Francisco; Pérez-Sáez, María José; Gómez-Gómez, Àlex; Haro, Noemí; Redondo Pachón, María Dolores; Dávalos Yerovi, Vanesa; Marco Navarro, Ester; Crespo Barrio, Marta; Pozo Mendoza, Óscar J., 1975-; Pascual Santos, Julio; FRAILMar Study GroupBackground. Sarcopenia and frailty are often overlooked in assessing kidney transplant (KT) candidates with chronic kidney disease (CKD), potentially leading to poor post-transplant outcomes. This study aimed to identify metabolites associated with frailty and sarcopenia in KT candidates from the FRAILMar study. Methods. Between June 2016 and June 2020, we evaluated frailty and sarcopenia in 173 KT candidates using the Physical Frailty Phenotype and EGWSOP-2 criteria, respectively. Seventy-five metabolic markers from targeted pathways, previously linked to CKD, sarcopenia or frailty, were measured in serum samples. These markers were analyzed using adjusted and weighted generalized linear models. Metabolomic data were integrated with multi-modal data, such as comorbidities, using a factor-based integration algorithm to identify metabolic phenotypes. Results. Increased metabolites related to energy metabolism and essential amino acids were associated with frailty, mainly Krebs cycle intermediates. Sarcopenic KT candidates showed lower levels of aromatic amino acids, and lower protein/muscle metabolism, energy metabolism and neurotransmission compared with non-sarcopenic patients. Unsupervised multi-modal integration revealed a high-risk metabolic phenotype characterized by the presence of sarcopenia, diabetes mellitus and low body mass index, with alterations in branched-chain amino acids and high activity of lactate dehydrogenase enzyme. Conclusions. Frailty and sarcopenia are common among KT candidates, and their metabolic status reveals notable disruptions in energy and amino acid metabolism. These findings highlight the value of a detailed metabolic assessment to more accurately evaluate patient health status prior to transplantation.Item type: Item , Asymptomatic inflammatory bowel disease diagnosed during colorectal cancer population screening in Catalonia: characteristics and natural history(Wolters Kluwer (LWW), 2025) Brunet-Mas, Eduard; Márquez Mosquera, Lucía; Calvet, XavierIntroduction: Inflammatory bowel disease (IBD) is usually diagnosed when symptomatic. Prognosis and evolution of preclinical IBD is largely unknown. However, colorectal cancer screening programs (CRCSP) detect a subset of patients with IBD with no symptoms. The aim of this study was to describe the natural history of asymptomatic IBD diagnosed through CRCSP. Methods: An observational, longitudinal, and retrospective study was performed at 22 centers in Catalonia between January 2010 and December 2019 including patients with asymptomatic IBD detected in the CRCSP. Demographic data and IBD characteristics, evolution, and treatment were recorded. Descriptive statistics and Kaplan-Meier analysis were used for the analysis. Data were given separately for IBD, Crohn's disease (CD), ulcerative colitis (UC), and IBD unclassified (IBDU). Results: One hundred eighty-eight patients were included: 103 UC (54.8%), 60 CD (31.9%), and 25 IBDU (13.3%). Sixty-six (35.1%) were women, and the average age was 59.9 ± 5.9 years. Sixty-four patients (34.0%) developed symptoms after a median follow-up of 35.6 months. Diarrhea was the most frequent symptom for CD and IBDU (25.4% and 11.5%, respectively) and blood in stools for UC (21.4%). The median time to first symptom was 11.6 months. Treatment was prescribed in 135 patients (72.2%); mesalazine was the most prescribed drug (123 patients; 65.4%). Thirteen patients (6.9%) required biological treatment. None underwent surgery. Discussion: Around one-third of asymptomatic patients with IBD developed symptoms after a medium follow-up of 3 years. Only 6.9% required biological treatment, and none required surgery. Overall, prognosis of asymptomatic IBD seems better.Item type: Item , Curs de pragmàtica: una introducció a l'estudi del significat en context(Universitat Pompeu Fabra, 2026) Mayol, LaiaCom indica el títol, aquest llibre té com a objectiu oferir una introducció al camp de la pragmàtica, l'estudi del significat lingüístic en context. Està pensat principalment per a estudiants de grau o de màster en l'àmbit de les llengües o de la lingüística, però també pot ser útil per a qualsevol persona interessada a descobrir què és la pragmàtica. Per seguir el llibre amb facilitat, és recomanable haver fet, com a mínim, un curs d'introducció a la lingüística i estar familiaritzat amb les nocions més bàsiques del camp. Tanmateix, el text pressuposa molt pocs coneixements previs de lingüística i s'hi presenten tots els conceptes necessaris per poder seguir les explicacions.