Tesis doctorals llegides a la UPF en format digital en accés obert introduïdes a la plataforma TDX (Tesis Doctorals en Xarxa), on també es poden consultar tesis d'altres centres.
Appropriate regulation of gene expression is necessary for correct development and homeostasis of organisms. Epigenetic mechanisms represent an additional layer of information, besides the genetic sequence, crucial for the ...
Pancreatic ductal adenocarcinoma (PDA) is one of the most aggressive tumors; mostly due to its lack of symptoms, resulting in late diagnosis, and also due to the presence of an aggressive tumor microenvironment. Importantly, ...
Maldonado Barragán, Ana Margarita, 1988-(2021-03-26)
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To reveal how RBM10 loss contributes to development and cancer we have established Rbm10 constitutive and conditional knockout mouse models and have analyzed phenotypes at the organismal and ...
Cytomegalovirus (CMV) infection in kidney transplant recipients (KTR) is frequent and may reduce graft and patient survival. T lymphocytes are essential to control the virus, which promotes the adaptive differentiation of ...
This thesis explores the problem of compatibility between generations in the field of
Digital Television, and proposes solutions to this problem. Since its inception, the DTV
has been under development without taking into ...
Capturing sounds on a recording medium to enable their preservation and reproduction started to be possible during the industrial revolution of the 19th century, originally achieved through mechanic and acoustic devices, ...
Objective: To examine health inequities in the working population of Latin America and the
Caribbean (LAC) according to sex, age, level of study, occupation and formality or
informality in employment.
Methods: We collected ...
In this thesis I elaborate on three reasons why religious exemptions from generally applicable laws are not publicly justifiable in a liberal democratic society. First, mere claims of the form “God says so and my conscience ...
In the eukaryotic nucleus, DNA, wrapped around a core of histone proteins. Replication-coupled histones can be exchanged by histone variants. In mammals, H2A can be replaced by three distinct macroH2A proteins. Alternative ...
Continuous C/EBPa expression converts B cells into
macrophages while its transient upregulation before the
Yamanaka factors yields highly efficient iPSC
reprogramming. C/EBP members regulate Il6 pathway
genes and IL-6 ...
Infectious diseases have affected humanity since its apparition in Africa 300,000 years ago. Demographic changes associated to the Neolithic transition, and ensuing population movements, have facilitated the emergence and ...
Mental disorders have become a major concern in public health, since they are one of the main causes of the overall disease burden worldwide. Depressive disorders are the most common mental illnesses, and they constitute ...
X-Chromosome Reactivation (XCR) occurs in the epiblast cells of the blastocyst and in germ cells,
thereby coupling XCR with pluripotency. We performed a screen in iPS cells by knocking down the
expression of candidate genes ...
Martín Salguero, Ana María(Universitat Pompeu Fabra, 2021-03-25)
The aim of the dissertation is to explore behavioral and neuropsychological correlates of elementary
deductive processes in infants and adults. To this purpose, we introduce a novel non-verbal task
presenting scenes ...
Elliptic curves with a bilinear map, or pairing, have a rich algebraic structure that has been fundamental to develop practical Non-Interactive Zero-Knowledge (NIZK) proofs.
On the theoretical side, we explore how efficient ...
In neuropsychiatry, the development of brain imaging and dedicated data analysis for personalized medicine promises to predict both the evolution of diseases and responses of treatments. The ability to estimate the time ...
Jean Epstein escribía que, al filmar un rostro de cerca, el cinematógrafo había sido capaz de mostrar el alma humana. Así es como, en el período mudo, se instituyó la teoría de la fotogenia. Esta tesis parte de una voluntad ...
This thesis, entitled The International Legal Regime Of Submarine Cables: A Global Public Interest Regime, aims to analyze the legal regime governing submarine cables, identify its deficiencies and examine how they might ...
Entre los misioneros que evangelizaron en China (siglos XVI y XVII), destaca notablemente el franciscano Pedro de la Piñuela [石铎琭, Shi duolu] (1650-1704). Él era un criollo que nació en Nueva España y entró en China en el ...
La jurisprudencia del TEDH señala de manera recurrente que, una vez declarada la violación del Convenio, los Estados son libres para elegir los medios de reparación. Partiendo de esta premisa, en esta tesis defenderé que ...