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A finer-grained linguistic profile of Alzheimer’s disease and Mild Cognitive Impairment

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dc.contributor.author Chapin, Kayla B.
dc.contributor.author Clarke, Natasha
dc.contributor.author Garrard, Peter
dc.contributor.author Hinzen, Wolfram
dc.date.accessioned 2022-03-29T06:44:55Z
dc.date.available 2022-03-29T06:44:55Z
dc.date.issued 2022
dc.identifier.citation Chapin K, Clarke N, Garrard P, Hinzen W. A finer-grained linguistic profile of Alzheimer’s disease and Mild Cognitive Impairment. J Neurolinguistics. 2022;63:101069. DOI: 10.1016/j.jneuroling.2022.101069
dc.identifier.issn 0911-6044
dc.identifier.uri http://hdl.handle.net/10230/52790
dc.description Conté: Appendix A. Supplementary data
dc.description.abstract Linguistic measures in spontaneous speech have shown promise in the early detection of Alzheimer’s disease (AD), but it remains unknown which specific linguistic variables show sensitivity and how language decline relates to primary memory deficits. We hypothesized that a set of finegrained linguistic variables relating specifically to forms of syntactic complexity involved in referencing objects and events as part of episodes would show sensitivity. We tested this in speech samples obtained from a picture description task, maximally isolating language deficits from the confound of episodic memory (EM) demands. 105 participants were split into Mild Cognitive Impairment (MCI), Mild-to-Moderate AD, and healthy controls (HC). Results showed that groups did not differ on generic linguistic variables such as number or length of utterances. However, AD relative to HC produced fewer embedded adjunct clauses, indefinite noun phrases, and Aspect marking, with moderate-to-large effect sizes. MCI compared to HC produced fewer adjunct clauses as well as fewer adverbial adjuncts. Together, these results confirm language impairment in AD and MCI at the level of specific linguistic variables relating to structures required for endowing narrative with specificity and episodic richness, independently of EM demands.
dc.description.sponsorship This work was supported by grants MR/N013638/1 (St. Georges University of London, United Kingdom), FI-DGR, and SGR-1265 (both Generalitat de Catalunya), and by PID 2019-105241 GB-I00/AEI/10.13039/501100011033 financed by the Ministerio de Ciencia, Innovacion y Universidades (MCIU) and by the Agencia Estatal de Investigacion (AEI).
dc.format.mimetype application/pdf
dc.language.iso eng
dc.publisher Elsevier
dc.relation.ispartof Journal of Neurolinguistics. 2022;63:101069
dc.rights © 2022 The Authors. Published by Elsevier Ltd. This is an open access article under the CC BY-NC-ND license
dc.rights.uri https://creativecommons.org/licenses/by-nc-nd/4.0/
dc.title A finer-grained linguistic profile of Alzheimer’s disease and Mild Cognitive Impairment
dc.type info:eu-repo/semantics/article
dc.identifier.doi http://dx.doi.org/10.1016/j.jneuroling.2022.101069
dc.subject.keyword Alzheimer’s disease
dc.subject.keyword Memory
dc.subject.keyword Spontaneous connected speech
dc.subject.keyword Reference
dc.subject.keyword Grammar
dc.subject.keyword Specificity
dc.relation.projectID info:eu-repo/grantAgreement/ES/2PE/PID2019-110120RB-I00
dc.rights.accessRights info:eu-repo/semantics/openAccess
dc.type.version info:eu-repo/semantics/publishedVersion

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