A finer-grained linguistic profile of Alzheimer’s disease and Mild Cognitive Impairment

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• dc.contributor.author Chapin, Kayla B.
• dc.contributor.author Clarke, Natasha
• dc.contributor.author Garrard, Peter
• dc.contributor.author Hinzen, Wolfram
• dc.date.accessioned 2022-03-29T06:44:55Z
• dc.date.available 2022-03-29T06:44:55Z
• dc.date.issued 2022
• dc.description Conté: Appendix A. Supplementary data
• dc.description.abstract Linguistic measures in spontaneous speech have shown promise in the early detection of Alzheimer’s disease (AD), but it remains unknown which specific linguistic variables show sensitivity and how language decline relates to primary memory deficits. We hypothesized that a set of finegrained linguistic variables relating specifically to forms of syntactic complexity involved in referencing objects and events as part of episodes would show sensitivity. We tested this in speech samples obtained from a picture description task, maximally isolating language deficits from the confound of episodic memory (EM) demands. 105 participants were split into Mild Cognitive Impairment (MCI), Mild-to-Moderate AD, and healthy controls (HC). Results showed that groups did not differ on generic linguistic variables such as number or length of utterances. However, AD relative to HC produced fewer embedded adjunct clauses, indefinite noun phrases, and Aspect marking, with moderate-to-large effect sizes. MCI compared to HC produced fewer adjunct clauses as well as fewer adverbial adjuncts. Together, these results confirm language impairment in AD and MCI at the level of specific linguistic variables relating to structures required for endowing narrative with specificity and episodic richness, independently of EM demands.
• dc.description.sponsorship This work was supported by grants MR/N013638/1 (St. Georges University of London, United Kingdom), FI-DGR, and SGR-1265 (both Generalitat de Catalunya), and by PID 2019-105241 GB-I00/AEI/10.13039/501100011033 financed by the Ministerio de Ciencia, Innovacion y Universidades (MCIU) and by the Agencia Estatal de Investigacion (AEI).
• dc.format.mimetype application/pdf
• dc.identifier.citation Chapin K, Clarke N, Garrard P, Hinzen W. A finer-grained linguistic profile of Alzheimer’s disease and Mild Cognitive Impairment. J Neurolinguistics. 2022;63:101069. DOI: 10.1016/j.jneuroling.2022.101069
• dc.identifier.doi http://dx.doi.org/10.1016/j.jneuroling.2022.101069
• dc.identifier.issn 0911-6044
• dc.identifier.uri http://hdl.handle.net/10230/52790
• dc.language.iso eng
• dc.publisher Elsevier
• dc.relation.ispartof Journal of Neurolinguistics. 2022;63:101069
• dc.relation.projectID info:eu-repo/grantAgreement/ES/2PE/PID2019-110120RB-I00
• dc.rights © 2022 The Authors. Published by Elsevier Ltd. This is an open access article under the CC BY-NC-ND license
• dc.rights.accessRights info:eu-repo/semantics/openAccess
• dc.rights.uri https://creativecommons.org/licenses/by-nc-nd/4.0/
• dc.subject.keyword Alzheimer’s disease
• dc.subject.keyword Memory
• dc.subject.keyword Spontaneous connected speech
• dc.subject.keyword Reference
• dc.subject.keyword Grammar
• dc.subject.keyword Specificity
• dc.title A finer-grained linguistic profile of Alzheimer’s disease and Mild Cognitive Impairment
• dc.type info:eu-repo/semantics/article
• dc.type.version info:eu-repo/semantics/publishedVersion