Automatic identification of optimal transseptal puncture localization and device configuration with patient-specific haemodynamic modelling in patients undergoing left atrial appendage occlusion

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  • dc.contributor.author Saiz-Vivó, Marta
  • dc.contributor.author Mill, Jordi
  • dc.contributor.author Aguado, Ainhoa M.
  • dc.contributor.author Rochelle, Nahomy
  • dc.contributor.author Barredo, Anna
  • dc.contributor.author Albors Lucas, Carlos
  • dc.contributor.author Font Murillo, Mònica
  • dc.contributor.author Cepas-Guillen, Pedro L.
  • dc.contributor.author Freixa, Xavier
  • dc.contributor.author Barreiro-Perez, Manuel
  • dc.contributor.author Camara, Oscar
  • dc.date.accessioned 2025-09-15T06:16:22Z
  • dc.date.embargoEnd info:eu-repo/date/embargoEnd/2026-09-12
  • dc.date.issued 2025
  • dc.description.abstract Atrial Fibrillation affects 33.5 million people worldwide. It is associated with life-threatening consequences such as stroke, placing a heavy burden on healthcare resources. Stroke prevention is based on administering direct oral anticoagulants (DOACs) and for those contraindicated left atrial appendage occlusion (LAAO) is recommended. Still, after LAAO, a short-term period of anticoagulation is needed to avoid device-related thrombus. Predicting the minimal dose of anticoagulant administered after the intervention might reduce DOAC’s side effects. Therefore, we present a multi-therapeutic model that combines LAAO flow simulations with DOAC monitoring. Six simulations representing different clinical practice scenarios are performed: LAAO covering and uncovering the pulmonary ridge with or without 2.5 mg apixaban. Results show that applying 2.5 mg of Apixaban reduces the risk of DRT no matter the position of the occluder in the pulmonary ridge. Future steps should address the integration of more anticoagulant therapies. Despite being a proof-of-concept, we successfully developed a multi-therapeutic approach that evaluates the formation of DRT in different clinical scenarios.
  • dc.description.sponsorship This study was funded by the Spanish Ministry of Science (GENERALITAAT: PID2022-143239OB-I00) and the European Union (GA 101136438- GEMINI and 101016496 Sim-CardioTest). Views and opinions expressed are however those of the author(s) only and do not necessarily reflect those of the European Union or the Agency. Neither the European Union nor the granting authority can be held responsible for them.
  • dc.embargo.liftdate 2026-09-12
  • dc.format.mimetype application/pdf
  • dc.identifier.citation Saiz-Vivó M, Mill J, Aguado AM, Rochelle N, Barredo A, Albors C, et al. Automatic identification of optimal transseptal puncture localization and device configuration with patient-specific haemodynamic modelling in patients undergoing left atrial appendage occlusion. In: Chabiniok R, Zou Q, Hussain T, Nguyen HH, Zaha VG, Gusseva M, editors. 13th International Conference Functional Imaging and Modeling of the Heart (FIMH 2025); 2025 June 1-5; Texas, USA. Cham: Springer; 2025. p 330-40. DOI: 10.10
  • dc.identifier.uri http://hdl.handle.net/10230/71189
  • dc.language.iso eng
  • dc.publisher Springer
  • dc.relation.ispartof 13th International Conference Functional Imaging and Modeling of the Heart (FIMH 2025); 2025 June 1-5; Texas, USA.
  • dc.relation.projectID info:eu-repo/grantAgreement/ES/3PE/PID2022-143239OB-I00
  • dc.rights © The Author(s), under exclusive license to Springer Nature Switzerland AG 2025
  • dc.rights.accessRights info:eu-repo/semantics/embargoedAccess
  • dc.subject.keyword Left atrial appendage occlusion
  • dc.subject.keyword Haemodynamic modelling
  • dc.subject.keyword Transseptal puncture
  • dc.title Automatic identification of optimal transseptal puncture localization and device configuration with patient-specific haemodynamic modelling in patients undergoing left atrial appendage occlusion
  • dc.type info:eu-repo/semantics/conferenceObject
  • dc.type.version info:eu-repo/semantics/acceptedVersion