BONEs not CATs attract DOGs: semantic context effects for picture naming in the lesioned language network

Mostra el registre complet Registre parcial de l'ítem

• dc.contributor.author Pino, Danièle
• dc.contributor.author Mädebach, Andreas
• dc.contributor.author Jescheniak, Jörg D.
• dc.contributor.author Regenbrecht, Frank
• dc.contributor.author Obrig, Hellmuth
• dc.date.accessioned 2022-11-25T07:01:06Z
• dc.date.available 2022-11-25T07:01:06Z
• dc.date.issued 2022
• dc.description.abstract The breakdown of rapid and accurate retrieval of words is a hallmark of aphasic speech and a prime target of therapeutic intervention. Complementary, psycho- and neurolinguistic research have developed a spectrum of models, how and by which neuronal network uncompromised speakers can rely on remarkable lexical retrieval capacities. Motivated by both lines of research we invited 32 participants with a chronic left hemispheric brain lesion to name pictures in the presence of distractor words. This picture-word-interference (PWI) paradigm is widely used in psycho- and neurolinguistic research. We find that also after brain lesion categorically related words (CAT → [dog]picture) impede naming, while associatively related words (BONE → [dog]picture) ease access, when compared to unrelated distractor words. The effects largely affecting latencies in neurotypical populations, are reproduced for error rate in our participants with lesions in the language network. Unsurprisingly, overall naming abilities varied greatly across patients. Notably, however, the two effects (categorical interference / associative facilitation) differ between participants. Correlating performance with lesion patterns we find support for the notion of a divergence of brain areas affording different aspects of the task: (i) lesions in the left middle temporal gyurs (MTG) deteriorate overall naming, confirming previous work; more notably, (ii) lesions comprising the inferior frontal hub (inferior frontal gyrus, IFG) of the language-network increase the interference effect for the categorical condition; on the contrary, (iii) lesions to the mid-to-posterior temporal hub (posterior middle and superior temporal gyri, pMTG/ pSTG) increase the facilitatory effect for the associative condition on error rates. The findings can be accommodated in a neuro-linguistic framework, which localizes lexical activation but also lexical interference in posterior parts of the language network (pMTG/pITG); conversely, selection between co-activated categorically related entries is afforded by frontal language areas (IFG). While purely experimental in nature our study highlights that lesion site differentially influences specific aspects of word retrieval. Since confrontational naming is a cornerstone of aphasia rehabilitation, this may be of note when designing and evaluating novel therapeutic regimes.en
• dc.format.mimetype application/pdf
• dc.identifier.citation Pino D, Mädebach A, Jescheniak JD, Regenbrecht F, Obrig H. BONEs not CATs attract DOGs: semantic context effects for picture naming in the lesioned language network. NeuroImage. 2022;246:118767. DOI: 10.1016/j.neuroimage.2021.118767
• dc.identifier.doi http://dx.doi.org/10.1016/j.neuroimage.2021.118767
• dc.identifier.issn 1053-8119
• dc.identifier.uri http://hdl.handle.net/10230/55002
• dc.language.iso eng
• dc.publisher Elsevier
• dc.relation.ispartof NeuroImage. 2022;246:118767
• dc.rights © 2021 The Authors. Published by Elsevier Inc. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/)
• dc.rights.accessRights info:eu-repo/semantics/openAccess
• dc.rights.uri http://creativecommons.org/licenses/by-nc-nd/4.0/
• dc.subject.keyword Language productionen
• dc.subject.keyword Semantic interferenceen
• dc.subject.keyword Picture-word interference paradigmen
• dc.subject.keyword Aphasiaen
• dc.subject.keyword Voxel-based lesion-symptom mappingen
• dc.title BONEs not CATs attract DOGs: semantic context effects for picture naming in the lesioned language network
• dc.type info:eu-repo/semantics/article
• dc.type.version info:eu-repo/semantics/publishedVersion