Structural connectivity in ventral language pathways characterizes non‑verbal autism

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• dc.contributor.author Olivé, Guillem
• dc.contributor.author Slušná, Dominika
• dc.contributor.author Vaquero, Lucía
• dc.contributor.author Muchart, Jordi
• dc.contributor.author Rodríguez-Fornells, Antoni
• dc.contributor.author Hinzen, Wolfram
• dc.date.accessioned 2022-03-29T06:45:09Z
• dc.date.available 2022-03-29T06:45:09Z
• dc.date.issued 2022
• dc.description Conté: Suplementary data
• dc.description.abstract Language capacities in autism spectrum disorders (ASD) range from normal scores on standardized language tests to absence of functional language in a substantial minority of 30% of individuals with ASD. Due to practical difculties of scanning at this severe end of the spectrum, insights from MRI are scarce. Here we used manual deterministic tractography to investigate, for the frst time, the integrity of the core white matter tracts defning the language connectivity network in non-verbal ASD (nvASD): the three segments of the arcuate (AF), the inferior fronto-occipital (IFOF), the inferior longitudinal (ILF) and the uncinate (UF) fasciculi, and the frontal aslant tract (FAT). A multiple case series of nine individuals with nvASD were compared to matched individuals with verbal ASD (vASD) and typical development (TD). Bonferroni-corrected repeated measure ANOVAs were performed separately for each tract—Hemisphere (2:Left/Right) × Group (3:TD/vASD/ nvASD). Main results revealed (i) a main efect of group consisting in a reduction in fractional anisotropy (FA) in the IFOF in nvASD relative to TD; (ii) a main efect of group revealing lower values of radial difusivity (RD) in the long segment of the AF in nvASD compared to vASD group; and (iii) a reduced volume in the left hemisphere of the UF when compared to the right, in the vASD group only. These results do not replicate volumetric diferences of the dorsal language route previously observed in nvASD, and instead point to a disruption of the ventral language pathway, in line with semantic defcits observed behaviourally in this group.
• dc.description.sponsorship Open Access funding provided thanks to the CRUECSIC agreement with Springer Nature. Supported by an ‘advanced research group’ grant to the Grammar and Cognition Lab (2017 SGR 1265, W.H.), and grants FFI2013-40526P and PID2019-110120RBI00/AEI/10.13039/501100011033 by the Ministerio de Ciencia, Innovación y Universidades (MCIU) and the Agencia Estatal de Brain Structure and Function 1 3 Investigación (AEI) (W.H.), and two predoctoral research grants: one from Generalitat de Catalunya (AGAUR) & European Social Found (2018FI_B_00860, D.S), the other from Government of Andorra: Guillem Olivé Cadena acknowledges the Government of Andorra from a predoctoral grant, (ATC0XX-AND-2020/2021, G.O.). The funders had no role in the study design, data collection and analysis, decision to publish, or preparation of the manuscript
• dc.format.mimetype application/pdf
• dc.identifier.citation Olivé G, Slušná D, Vaquero L, Muchart-López J, Rodríguez-Fornells A, Hinzen W. Structural connectivity in ventral language pathways characterizes non-verbal autism. Brain Struct Funct. 2022;227:1817–29. DOI: 10.1007/s00429-022-02474-1
• dc.identifier.doi http://dx.doi.org/10.1007/s00429-022-02474-1
• dc.identifier.issn 1863-2653
• dc.identifier.uri http://hdl.handle.net/10230/52792
• dc.language.iso eng
• dc.publisher Springer
• dc.relation.ispartof Brain Structure and Function. 2022.
• dc.relation.projectID info:eu-repo/grantAgreement/ES/1PE/FFI2013-40526P
• dc.relation.projectID info:eu-repo/grantAgreement/ES/2PE/PID2019-110120RB-I00
• dc.rights © The Author(s) 2022. This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.
• dc.rights.accessRights info:eu-repo/semantics/openAccess
• dc.rights.uri https://creativecommons.org/licenses/by/4.0/
• dc.subject.keyword MRI
• dc.subject.keyword DWI
• dc.subject.keyword Tractography
• dc.subject.keyword Autism
• dc.subject.keyword Non-verbal
• dc.subject.keyword Language
• dc.title Structural connectivity in ventral language pathways characterizes non‑verbal autism
• dc.type info:eu-repo/semantics/article
• dc.type.version info:eu-repo/semantics/publishedVersion