Sensitivity analysis of left atrial wall modeling approaches and inlet/outlet boundary conditions in fluid simulations to predict thrombus formation

Mostra el registre complet Registre parcial de l'ítem

• dc.contributor.author Albors, Carlos
• dc.contributor.author Mill, Jordi
• dc.contributor.author Kjeldsberg, Henrik A
• dc.contributor.author Viladés-Medel, David
• dc.contributor.author Olivares Miyares, Andy Luis
• dc.contributor.author Valen-Sendstad, Kristian
• dc.contributor.author Camara, Oscar
• dc.date.accessioned 2024-04-16T14:39:26Z
• dc.date.available 2024-04-16T14:39:26Z
• dc.date.issued 2022
• dc.description Comunicació presentada a 13th International Workshop, STACOM 2022, conjuntament amb MICCAI 2022, celebrada el 18 de setembre de 2022 a Singapur.
• dc.description.abstract In-silico fluid simulations of the left atria (LA) in atrial fibrillation (AF) patients can help to describe and relate patient-specific morphologies and complex flow haemodynamics with the pathophysiological mechanisms behind thrombus formation. Even in AF patients, LA wall motion plays a non-negligible role in LA function and blood flow patterns. However, obtaining 4D LA wall dynamics from patient-specific data is not an easy task due to current image resolution limitations. Therefore, several approaches have been proposed in the literature to include left atrial wall motion in fluid simulations, being necessary to benchmark them in relation to their estimations on thrombogenic risk. In this work, we present results obtained with computational fluid dynamic simulations of LA geometries from a control and an AF patient with different left atrial wall motion approaches: 1) assuming rigid walls; 2) with a passive movement of the mitral valve annulus plane from a dynamic mesh approach based on springs (DM-SB); and 3) imposing LA wall deformation extracted from dynamic computed tomography (DM-dCT) images. Different strategies for the inlet/outlet boundary conditions were also tested. The DM-dCT approach was the one providing simulation results closer to velocity curves extracted from the reference echocardiographic data, whereas the rigid wall strategy over-estimated the risk of thrombus formation.
• dc.description.sponsorship This project has received funding from the European Union’s Horizon 2020 research and innovation programme under grant agreement No 101016496 (SimCardioTest).
• dc.format.mimetype application/pdf
• dc.identifier.citation Albors C, Mill J, Kjeldsberg HA, Viladés Medel D; Olivares AL, et al.Sensitivity analysis of left atrial wall modeling approaches and inlet/outlet boundary conditions in fluid simulations to predict thrombus formation. In: Camara O, Puyol-Antón E, Qin C, Sermesant M, Suinesiaputra A, Wang S, Young A, editors. STACOM 2022: Statistical atlases and computational models of the heart. Regular and CMRxMotion challenge papers; 2022 Sep 18; Singapore. Cham: Springer; 2022. p. 179–89. DOI: 10.1007/978-3-031-23443-9_17
• dc.identifier.doi http://dx.doi.org/10.1007/978-3-031-23443-9_17
• dc.identifier.uri http://hdl.handle.net/10230/59790
• dc.language.iso eng
• dc.publisher Springer
• dc.relation.projectID info:eu-repo/grantAgreement/EC/H2020/101016496
• dc.rights © Springer This is a author's accepted manuscript of: Albors C, Mill J, Kjeldsberg HA, Viladés Medel D; Olivares AL, et al.Sensitivity analysis of left atrial wall modeling approaches and inlet/outlet boundary conditions in fluid simulations to predict thrombus formation. In: STACOM 2022: Statistical atlases and computational models of the heart. Regular and CMRxMotion challenge papers; 2022 Sep 18; Singapore. Cham: Springer; 2022. p. 179–89. DOI: 978-3-031-23443-9_17
• dc.rights.accessRights info:eu-repo/semantics/openAccess
• dc.subject.keyword Computational fluid dynamics
• dc.subject.keyword Atrial fibrillation
• dc.subject.keyword Left atrial appendage
• dc.subject.keyword Dynamic mesh
• dc.subject.keyword Thrombus formation
• dc.subject.keyword Boundary conditions
• dc.title Sensitivity analysis of left atrial wall modeling approaches and inlet/outlet boundary conditions in fluid simulations to predict thrombus formation
• dc.type info:eu-repo/semantics/conferenceObject
• dc.type.version info:eu-repo/semantics/acceptedVersion