Incorporation of the blood vessel wall into electroporation simulations

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• dc.contributor.author Qasrawi, Radwan Fayez Hasanca
• dc.contributor.author Silve, Louis Charles Arthurca
• dc.contributor.author Ivorra Cano, Antoni, 1974-ca
• dc.date.accessioned 2016-01-12T12:29:26Z
• dc.date.available 2016-01-12T12:29:26Z
• dc.date.issued 2015ca
• dc.description.abstract Electroporation can be used in living tissues in order to enhance the penetration of drugs or DNA plasmids or to destroy undesirable cells and it is typically performed by applying pulsed high voltages across needle electrodes. When used for ablation, it is often claimed that, in contrast with thermal ablation techniques, electroporation is not significant-ly impacted by the presence of large blood vessels because the heat sinking characteristic of these is not relevant for the elec-tric field distribution. However, large blood vessels do distort the electric field distribution because of their high inner con-ductivity and should be modeled during treatment planning. For such purpose, vessels may be simply modeled as homoge-neous regions whose conductivity is equal to that of the blood. Nevertheless, vessels are not just blood filled cavities within parenchyma; blood vessels contain a layered wall. The purpose of the present study is to check whether the blood vessel wall needs to be incorporated into the simulations. For that, a vessel wall electrical model has been implemented and it has been incorporated into 2D and 3D simulations in which treatment of a region that comprises a 5 mm thick artery within liver was modeled. The three main layers of a vessel wall (the intima, the media and the adventitia) were modeled as homogeneous ma-terials whose conductivity depends on the electric field magni-tude. The simulations show that the electric field error when the wall model is not incorporated is only marginally signifi-cant at the close vicinity of the vessel for low applied fields. Errors are insignificant beyond 1 or 2 mm. We conclude that in most electroporation scenarios it will not be necessary to simulate the blood vessel wall.en
• dc.description.sponsorship This work was supported in part by the Spanish Govern-ment through grants TEC2010-17285 and TEC2014-52383-C3 (TEC2014-52383-C3-2).
• dc.format.mimetype application/pdfca
• dc.identifier.citation Silve L, Qasrawi R, Ivorra A. Incorporation of the blood vessel wall into electroporation simulations. In: Jarm T, Kramar P, editors. 1st World Congress on Electroporation and Pulsed Electric Fields in Biology, Medicine and Food & Environmental Technologies; 2015 Sept 6-10; Portorož, Slovenia. Singapore: Springer Singapore, 2015. p. 223-227. DOI 10.1007/978-981-287-817-5_50.ca
• dc.identifier.doi http://dx.doi.org/10.1007/978-981-287-817-5_50
• dc.identifier.uri http://hdl.handle.net/10230/25554
• dc.language.iso engca
• dc.publisher Springerca
• dc.relation.ispartof Jarm T, Kramar P, editors. 1st World Congress on Electroporation and Pulsed Electric Fields in Biology, Medicine and Food & Environmental Technologies; 2015 Sept 6-10; Portorož, Slovenia. Singapore: Springer Singapore, 2015. p. 223-227
• dc.rights © Springer (The original publication is available at www.springerlink.com)ca
• dc.rights.accessRights info:eu-repo/semantics/openAccessca
• dc.subject.keyword Blood vessel
• dc.subject.keyword Blood vessel wall
• dc.subject.keyword Simulation
• dc.subject.keyword Electric field
• dc.subject.keyword Electroporation
• dc.title Incorporation of the blood vessel wall into electroporation simulationsca
• dc.type info:eu-repo/semantics/conferenceObjectca
• dc.type.version info:eu-repo/semantics/acceptedVersionca