Multi-therapeutic modelling for stroke prevention in atrial fibrillation: impact of the pulmonary ridge
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- dc.contributor.author Segarra-Queralt, Maria
- dc.contributor.author Barrouhou Berrouhou, Manal
- dc.contributor.author Molla, Marc
- dc.contributor.author Ribera Pascual, Marina
- dc.contributor.author Albors, Carlos
- dc.contributor.author Olivares Miyares, Andy Luis
- dc.contributor.author Bernardino Perez, Gabriel
- dc.contributor.author Mill, Jordi
- dc.contributor.author Camara, Oscar
- dc.date.accessioned 2025-09-15T06:16:08Z
- dc.date.embargoEnd info:eu-repo/date/embargoEnd/2026-09-12
- dc.date.issued 2025
- dc.description.abstract Atrial Fibrillation affects 33.5 million people worldwide. It is associated with life-threatening consequences such as stroke, placing a heavy burden on healthcare resources. Stroke prevention is based on administering direct oral anticoagulants (DOACs) and for those contraindicated left atrial appendage occlusion (LAAO) is recommended. Still, after LAAO, a short-term period of anticoagulation is needed to avoid device-related thrombus. Predicting the minimal dose of anticoagulant administered after the intervention might reduce DOAC’s side effects. Therefore, we present a multi-therapeutic model that combines LAAO flow simulations with DOAC monitoring. Six simulations representing different clinical practice scenarios are performed: LAAO covering and uncovering the pulmonary ridge with or without 2.5 mg apixaban. Results show that applying 2.5 mg of Apixaban reduces the risk of DRT no matter the position of the occluder in the pulmonary ridge. Future steps should address the integration of more anticoagulant therapies. Despite being a proof-of-concept, we successfully developed a multi-therapeutic approach that evaluates the formation of DRT in different clinical scenarios.
- dc.description.sponsorship This study was funded by the Spanish Ministry of Science (GENERALITAAT: PID2022-143239OB-I00) and the European Union (GA 101136438- GEMINI and 101016496 Sim-CardioTest). Views and opinions expressed are however those of the author(s) only and do not necessarily reflect those of the European Union or the Agency. Neither the European Union nor the granting authority can be held responsible for them.
- dc.embargo.liftdate 2026-09-12
- dc.format.mimetype application/pdf
- dc.identifier.citation Segarra-Queralt M, Barrouhou-Berrouhou M, Molla M, Ribera M, Albors C, Olivares AL, et al. Multi-therapeutic modelling for stroke prevention in atrial fibrillation: impact of the pulmonary ridge. In: Chabiniok R, Zou Q, Hussain T, Nguyen HH, Zaha VG, Gusseva M, editors. 13th International Conference Functional Imaging and Modeling of the Heart (FIMH 2025); 2025 June 1-5; Texas, USA. Cham: Springer; 2025. p 197–205. DOI: 10.1007/978-3-031-94559-5_18
- dc.identifier.uri http://hdl.handle.net/10230/71188
- dc.language.iso eng
- dc.publisher Springer
- dc.relation.ispartof 13th International Conference Functional Imaging and Modeling of the Heart (FIMH 2025); 2025 June 1-5; Texas, USA. Cham: Springer; 2025.
- dc.relation.projectID info:eu-repo/grantAgreement/ES/3PE/PID2022-143239OB-I00
- dc.rights © 2025 The Author(s), under exclusive license to Springer Nature Switzerland AG
- dc.rights.accessRights info:eu-repo/semantics/embargoedAccess
- dc.subject.keyword Atrial fibrillation
- dc.subject.keyword Coagulation cascade
- dc.subject.keyword Anticoagulants
- dc.subject.keyword Left atrial appendage occlusion
- dc.title Multi-therapeutic modelling for stroke prevention in atrial fibrillation: impact of the pulmonary ridge
- dc.type info:eu-repo/semantics/conferenceObject
- dc.type.version info:eu-repo/semantics/acceptedVersion