Morphometry and functional connectivity of auditory cortex in school-age children with profound language disabilities: five comparative case studies

Mostra el registre complet Registre parcial de l'ítem

• dc.contributor.author Linke, Annika Carola
• dc.contributor.author Slušná, Dominika
• dc.contributor.author Kohli, Jiwandeep Singh
• dc.contributor.author Álvarez-Linera Prado, Juan
• dc.contributor.author Müller, Ralph-Axel
• dc.contributor.author Hinzen, Wolfram
• dc.date.accessioned 2022-03-29T06:45:18Z
• dc.date.available 2022-03-29T06:45:18Z
• dc.date.issued 2021
• dc.description.abstract Many neurodevelopmental conditions imply absent or severely reduced language capacities at school age. Evidence from functional magnetic resonance imaging is highly limited. We selected a series of five cases scanned with the same fMRI paradigm and the aim of relating individual language profiles onto underlying patterns of functional connectivity (FC) across auditory language cortex: three with neurogenetic syndromes (Coffin-Siris, Landau-Kleffner, and Fragile-X), one with idiopathic intellectual disability, one with autism spectrum disorder (ASD). Compared to both a group with typical development (TD) and a verbal ASD group (total N = 110), they all showed interhemispheric FC below two standard deviations of the TD mean. Children with higher language scores showed higher intrahemispheric FC between Heschl’s gyrus and other auditory language regions, as well as an increase of FC during language stimulation compared to rest. An increase of FC in forward vs. reversed speech in the posterior and middle temporal gyri was seen across all cases. The Coffin-Siris case, the most severe, also had the most anomalous FC patterns and showed reduced myelin content, while the Landau-Kleffner case showed reduced cortical thickness. These results suggest potential for neural markers and mechanisms of severe language processing deficits under highly heterogeneous etiological conditions.
• dc.description.sponsorship This research was supported by the Querer Foundation and by an ‘advanced research group’ grant to the Grammar and Cognition Lab [2017 SGR 1265, W.H.], and grants FFI2013-40526P and PID2019-110120RB-I00/AEI/10.13039/501100011033 by the Ministerio de Ciencia, Innovación y Universidades (MCIU) and the Agencia Estatal de Investigación (AEI) (W.H.), and a predoctoral research grant from the Generalitat de Catalunya (AGAUR) & European Social Found [2018FI_B_00860, D.S.]. The funders had no role in the study design, data collection and analysis, decision to publish, or preparation of the manuscript.
• dc.format.mimetype application/pdf
• dc.identifier.citation Linke A, Slušná D, Kohli JS, Álvarez-Linera Prado J, Müller RA, Hinzen W. Morphometry and functional connectivity of auditory cortex in school-age children with profound language disabilities: five comparative case studies. Brain Cogn. 2021;155:105822. DOI: 10.1016/j.bandc.2021.105822
• dc.identifier.doi http://dx.doi.org/10.1016/j.bandc.2021.105822
• dc.identifier.issn 0278-2626
• dc.identifier.uri http://hdl.handle.net/10230/52793
• dc.language.iso eng
• dc.publisher Elsevier
• dc.relation.ispartof Brain and Cognition. 2021;155:105822
• dc.relation.projectID info:eu-repo/grantAgreement/ES/1PE/FFI2013-40526P
• dc.relation.projectID info:eu-repo/grantAgreement/ES/2PE/PID2019-110120RB-I00
• dc.rights © 2021 The Authors. Published by Elsevier Inc. This is an open access article under the CC BY-NC-ND license
• dc.rights.accessRights info:eu-repo/semantics/openAccess
• dc.rights.uri https://creativecommons.org/licenses/by-nc-nd/4.0/
• dc.subject.keyword Functional connectivity
• dc.subject.keyword Auditory language network
• dc.subject.keyword Neurodevelopmental disorders
• dc.subject.keyword Cortical morphometry
• dc.subject.keyword Severe language deficits
• dc.title Morphometry and functional connectivity of auditory cortex in school-age children with profound language disabilities: five comparative case studies
• dc.type info:eu-repo/semantics/article
• dc.type.version info:eu-repo/semantics/publishedVersion