Brain correlates of speech perception in schizophrenia patients with and without auditory hallucinations

Mostra el registre complet Registre parcial de l'ítem

• dc.contributor.author Soler-Vidal, Joan
• dc.contributor.author Fuentes-Claramonte, Paola
• dc.contributor.author Salgado-Pineda, Pilar
• dc.contributor.author Ramiro, Nuria
• dc.contributor.author García-León, María Ángeles
• dc.contributor.author Llanos Torres, María
• dc.contributor.author Arévalo, Antonio
• dc.contributor.author Guerrero-Pedraza, Amalia
• dc.contributor.author Munuera, Josep
• dc.contributor.author Sarró, Salvador
• dc.contributor.author Salvador, Raymond
• dc.contributor.author Hinzen, Wolfram
• dc.contributor.author McKenna, Peter J.
• dc.contributor.author Pomarol-Clotet, Edith
• dc.date.accessioned 2023-03-14T07:16:44Z
• dc.date.available 2023-03-14T07:16:44Z
• dc.date.issued 2022
• dc.description.abstract The experience of auditory verbal hallucinations (AVH, “hearing voices”) in schizophrenia has been found to be associated with reduced auditory cortex activation during perception of real auditory stimuli like tones and speech. We re-examined this finding using 46 patients with schizophrenia (23 with frequent AVH and 23 hallucination-free), who underwent fMRI scanning while they heard words, sentences and reversed speech. Twenty-five matched healthy controls were also examined. Perception of words, sentences and reversed speech all elicited activation of the bilateral superior temporal cortex, the inferior and lateral prefrontal cortex, the inferior parietal cortex and the supplementary motor area in the patients and the healthy controls. During the sentence and reversed speech conditions, the schizophrenia patients as a group showed reduced activation in the left primary auditory cortex (Heschl’s gyrus) relative to the healthy controls. No differences were found between the patients with and without hallucinations in any condition. This study therefore fails to support previous findings that experience of AVH attenuates speech-perception-related brain activations in the auditory cortex. At the same time, it suggests that schizophrenia patients, regardless of presence of AVH, show reduced activation in the primary auditory cortex during speech perception, a finding which could reflect an early information processing deficit in the disorder.
• dc.description.sponsorship This work was supported by the CIBERSAM and the Catalonian Government (2017SGR01271 to EP-C and 2017SGR1265 to WH). Also by a grant from the Plan Nacional de I+D+i 2013–2016: Juan de la Cierva-formación contract (FJCI-2015-25278 to PF-C) and two projects from the Ministerio de Ciencia, Innovación y Universidades (MCIU) y la Agencia Estatal de Investigación (AEI), FFI2016-77647-C2-2-P to WH and PS-P and PID2019-110120RBI00/AEI/10.13039/501100011033 to WH); and by the Instituto de Salud Carlos III, co-funded by European Union (ERDF/ESF, “Investing in your future”): Miguel Servet Research contracts (CPII13/00018 to RS and MS10/00596 to EP-C), Sara Borrell contract (CD19/00149 to PF-C) and Research Project Grants (PI18/00880 to PM).
• dc.format.mimetype application/pdf
• dc.identifier.citation Soler-Vidal J, Fuentes-Claramonte P, Salgado-Pineda P, Ramiro N, García-León MA, Llanos Torres M, Arévalo A, Guerrero-Pedraza A, Munuera J, Sarró S, Salvador R, Hinzen W, McKenna P, Pomarol-Clotet E. Brain correlates of speech perception in schizophrenia patients with and without auditory hallucinations. PLoS One. 2022;17(12):e0276975. DOI: 10.1371/journal.pone.0276975
• dc.identifier.doi http://dx.doi.org/10.1371/journal.pone.0276975
• dc.identifier.issn 1932-6203
• dc.identifier.uri http://hdl.handle.net/10230/56220
• dc.language.iso eng
• dc.publisher Public Library of Science (PLoS)
• dc.relation.ispartof PLoS One. 2022;17(12):e0276975.
• dc.relation.isreferencedby https://doi.org/10.18112/openneuro.ds004302.v1.0.0
• dc.relation.isreferencedby https://openneuro.org/datasets/ds004302
• dc.relation.isreferencedby https://doi.org/10.1371/journal.pone.0276975.s001
• dc.relation.projectID info:eu-repo/grantAgreement/ES/2PE/PID2019-110120RBI00
• dc.relation.projectID info:eu-repo/grantAgreement/ES/1PE/FJCI-2015-25278
• dc.relation.projectID info:eu-repo/grantAgreement/ES/1PE/FFI2016-77647-C2-2-P
• dc.rights © 2022 Soler-Vidal et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
• dc.rights.accessRights info:eu-repo/semantics/openAccess
• dc.rights.uri http://creativecommons.org/licenses/by/4.0/
• dc.subject.keyword Schizophrenia
• dc.subject.keyword Auditory cortex
• dc.subject.keyword Hallucinations
• dc.subject.keyword Speech
• dc.subject.keyword Sensory perception
• dc.subject.keyword Occipital lobe
• dc.subject.keyword Parietal lobe
• dc.subject.keyword Prefrontal cortex
• dc.title Brain correlates of speech perception in schizophrenia patients with and without auditory hallucinations
• dc.type info:eu-repo/semantics/article
• dc.type.version info:eu-repo/semantics/publishedVersion