Impact of blood rheological strategies on the optimization of patient-specific LAAO configurations for thrombus assessment
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- dc.contributor.author Albors, Carlos
- dc.contributor.author Olivares Miyares, Andy Luis
- dc.contributor.author Iriart, Xavier
- dc.contributor.author Cochet, Hubert
- dc.contributor.author Mill, Jordi
- dc.contributor.author Camara, Oscar
- dc.date.accessioned 2024-04-16T14:39:30Z
- dc.date.available 2024-04-16T14:39:30Z
- dc.date.issued 2023
- dc.description Comunicació presentada a 12th International Conference, Functional Imaging and Modeling of the Heart, FIMH 2023, celebrada del 19 al 22 de juny de 2023 a Lió, França.
- dc.description.abstract Left atrial appendage occlusion devices (LAAO) are a feasible alternative for non-valvular atrial fibrillation (AF) patients at high risk of thromboembolic stroke and contraindication to antithrombotic therapies. However, optimal LAAO device configurations (i.e., size, type, location) remain unstandardized due to the large anatomical variability of the left atrial appendage (LAA) morphology, leading to a 4–6% incidence of device-related thrombus (DRT). In-silico simulations can be used to estimate the risk of DRT and identify the critical parameters, such as suboptimal device positioning. However, simulation outcomes depend a lot on a series of modelling assumptions such as blood behaviour. Therefore, in this work, we present fluid simulations results computed on two patient-specific LA geometries, using two different commercially available LAAO devices, located in two positions: 1) mimicking the real post-LAAO intervention configuration; and 2) an improved one better covering the pulmonary ridge for DRT prevention. Different blood modeling strategies were also tested. The results show flow re-circulations at low velocities with significant platelet accumulation in LAA-deep device positioning uncovering the pulmonary ridge, potentially leading to thrombus formation. In addition, assuming Newtonian blood behaviour may result in an overestimation of DRT risk.
- dc.description.sponsorship This project has received funding from the European Union’s Horizon 2020 research and innovation programme under grant agreement, No 101016496 (SimCardioTest).
- dc.format.mimetype application/pdf
- dc.identifier.citation Albors C, Olivares AL, Iriart X, Cochet H, Mill J, Camara O. Impact of blood rheological strategies on the optimization of patient-specific LAAO configurations for thrombus assessment. In: Bernard O, Clarysse P, Duchateau N, Ohayon J, Viallon M, editors. 12th International Conference, Functional Imaging and Modeling of the Heart, FIMH 2023; 2023 June 19-22; Lyon, France. Cham: Springer; 2023. p. 485-94. DOI: 10.1007/978-3-031-35302-4_50
- dc.identifier.uri http://hdl.handle.net/10230/59791
- dc.language.iso eng
- dc.publisher Springer
- dc.relation.projectID info:eu-repo/grantAgreement/EC/H2020/101016496
- dc.rights © Springer This is a author's accepted manuscript of: Albors C, Olivares AL, Iriart X, Cochet H, Mill J, Camara O. Impact of blood rheological strategies on the optimization of patient-specific LAAO configurations for thrombus assessment. In: 12th International Conference, Functional Imaging and Modeling of the Heart, FIMH 2023; 2023 June 19-22; Lyon, France. Cham: Springer; 2023. p. 485-94. DOI: 10.1007/978-3-031-35302-4_50
- dc.rights.accessRights info:eu-repo/semantics/openAccess
- dc.title Impact of blood rheological strategies on the optimization of patient-specific LAAO configurations for thrombus assessment
- dc.type info:eu-repo/semantics/conferenceObject
- dc.type.version info:eu-repo/semantics/acceptedVersion