GaN-based versatile waveform generator for biomedical applications of electroporation

Sarnago, Héctor; Burdío, José M.; García Sánchez, Tomás; Mir, Lluis M.; Álvarez Gariburo, Ignacio; Lucía, Óscar

doi:http://dx.doi.org/10.1109/ACCESS.2020.2996426

GaN-based versatile waveform generator for biomedical applications of electroporation

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Sarnago H, Burdío JM, García-Sánchez T, Mir LM, Álvarez-Gariburo I, Lucía O. GaN-based versatile waveform generator for biomedical applications of electroporation. IEEE Access. 2020 May 21;8:97196-203. DOI: 10.1109/ACCESS.2020.2996426

Abstract

Biomedical applications often require high-performance power supplies for diagnosis and treatment systems. In particular, modern electroporation techniques for cancer treatment require high-voltage generators with versatile waveform generation. In this context, sinusoidal waveform generation has been recently identified as beneficial for electrochemotherapy cancer treatments. This paper proposes the design of a high-voltage high-frequency arbitrary waveform generator taking advantage of Gallium Nitride (GaN) devices. The proposed converter has been designed and implemented, achieving a 1-MHz 2000-V output voltage. It has been electrically tested and applied to electrochemotherapy treatments in mice, demonstrating the feasibility of this proposal.