GaN-based versatile waveform generator for biomedical applications of electroporation

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• dc.contributor.author Sarnago, Héctor
• dc.contributor.author Burdío, José M.
• dc.contributor.author García Sánchez, Tomás
• dc.contributor.author Mir, Lluis M.
• dc.contributor.author Álvarez Gariburo, Ignacio
• dc.contributor.author Lucía, Óscar
• dc.date.accessioned 2020-07-08T08:35:07Z
• dc.date.available 2020-07-08T08:35:07Z
• dc.date.issued 2020
• dc.description.abstract Biomedical applications often require high-performance power supplies for diagnosis and treatment systems. In particular, modern electroporation techniques for cancer treatment require high-voltage generators with versatile waveform generation. In this context, sinusoidal waveform generation has been recently identified as beneficial for electrochemotherapy cancer treatments. This paper proposes the design of a high-voltage high-frequency arbitrary waveform generator taking advantage of Gallium Nitride (GaN) devices. The proposed converter has been designed and implemented, achieving a 1-MHz 2000-V output voltage. It has been electrically tested and applied to electrochemotherapy treatments in mice, demonstrating the feasibility of this proposal.en
• dc.description.sponsorship This work was supported in part by the Spanish Ministerio de economía y competitividad (MINECO) and Agencia Española de Investigación (AEI) under Project TEC2016-78358-R, in part by the Spanish Ministerio de Ciencia e Innovación (MICINN) under Project PIN2019, in part by the EU through the Fondo Europeo de Desarrollo Regional (FEDER) Program, in part by the Diputación General de Aragón-Fondo Social Europeo (DGA-FSE), and in part by the DGA under Project LMP106-18.
• dc.format.mimetype application/pdf
• dc.identifier.citation Sarnago H, Burdío JM, García-Sánchez T, Mir LM, Álvarez-Gariburo I, Lucía O. GaN-based versatile waveform generator for biomedical applications of electroporation. IEEE Access. 2020 May 21;8:97196-203. DOI: 10.1109/ACCESS.2020.2996426
• dc.identifier.doi http://dx.doi.org/10.1109/ACCESS.2020.2996426
• dc.identifier.issn 2169-3536
• dc.identifier.uri http://hdl.handle.net/10230/45087
• dc.language.iso eng
• dc.publisher Institute of Electrical and Electronics Engineers (IEEE)
• dc.relation.ispartof IEEE Access. 2020 May 21;8:97196-203
• dc.relation.projectID info:eu-repo/grantAgreement/ES/1PE/TEC2016-78358-R
• dc.rights This work is licensed under a Creative Commons Attribution 4.0 License. For more information, see https://creativecommons.org/licenses/by/4.0/
• dc.rights.accessRights info:eu-repo/semantics/openAccess
• dc.rights.uri https://creativecommons.org/licenses/by/4.0/
• dc.subject.keyword Electroporationen
• dc.subject.keyword Magnetic componentsen
• dc.subject.keyword Arbitrary waveform generatorsen
• dc.subject.keyword Capacitorsen
• dc.subject.keyword Wide bandgap semiconductoren
• dc.subject.keyword Cancer treatmenten
• dc.title GaN-based versatile waveform generator for biomedical applications of electroporationen
• dc.type info:eu-repo/semantics/article
• dc.type.version info:eu-repo/semantics/publishedVersion