Processing of linguistic deixis in people with schizophrenia, with and without auditory verbal hallucinations

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  • dc.contributor.author Fuentes-Claramonte, Paola
  • dc.contributor.author Soler-Vidal, Joan
  • dc.contributor.author Salgado-Pineda, Pilar
  • dc.contributor.author Ramiro, Nuria
  • dc.contributor.author Garcia-Leon, Maria Angeles
  • dc.contributor.author Cano, Ramon
  • dc.contributor.author Arévalo, Antonio
  • dc.contributor.author Munuera, Josep
  • dc.contributor.author Portillo, Francisco
  • dc.contributor.author Panicali, Francesco
  • dc.contributor.author Sarró, Salvador
  • dc.contributor.author Pomarol-Clotet, Edith
  • dc.contributor.author McKenna, Peter J.
  • dc.contributor.author Hinzen, Wolfram
  • dc.date.accessioned 2023-03-15T07:21:41Z
  • dc.date.available 2023-03-15T07:21:41Z
  • dc.date.issued 2022
  • dc.description.abstract Auditory verbal hallucinations (AVH) are a key symptom of schizophrenia (SZ) defined by anomalous perception of speech. Anomalies of processing external speech stimuli have also been reported in people with AVH, but it is unexplored which specific dimensions of language are processed differently. Using a speech perception task (passive listening), we here targeted the processing of deixis, a key dimension of language governing the contextual anchoring of speech in interpersonal context. We designed naturalistic speech stimuli that were either non-personal and fact-reporting (‘low-deixis’ condition), or else involved rich deictic devices such as the grammatical first and second persons, direct questions, and vocatives (‘high-deixis’). We asked whether neural correlates of deixis obtained with fMRI would distinguish patients with and without frequent hallucinations (AVH + vs AVH−) from controls and each other. Results showed that high-deixis relative to low-deixis was associated with clusters of increased activation in the bilateral middle temporal gyri extending into the temporal poles and the inferior parietal cortex, in all groups. The AVH + and AVH− groups did not differ. When unifying them, the SZ group as a whole showed altered activity in the precuneus, midline regions and inferior parietal cortex. These results fail to confirm deictic processing anomalies specific to patients with AVH, but reveal such anomalies across SZ. Hypoactivation of this network may relate to a cognitive mechanism for attributing and anchoring thought and referential speech content in context.
  • dc.description.sponsorship This research was supported by CIBERSAM and the Generalitat de Catalunya (AGAUR) (2017SGR1265 to WH, and 2017SGR1271 to EP-C), and grants PID2019-105241GB-I00/AEI/10.13039/501100011033 (to WH) and FFI2016-77647-C2-2-P (to WH and PS-P) provided by the Ministerio de Ciencia, Innovación y Universidades (MCIU) and the Agencia Estatal de Investigación (AEI). Also by the Instituto de Salud Carlos III, co-funded by the European Union (ERDF/ESF, “Investing in your future”): Sara Borrell contract (CD19/00149 to PF-C) and Research Project Grants (PI18/00880 to PM).
  • dc.format.mimetype application/pdf
  • dc.identifier.citation Fuentes-Claramonte P, Soler-Vidal J, Salgado-Pineda P, Ramiro N, Garcia-Leon MA, Cano R, Arévalo A, Munuera J, Portillo F, Panicali F, Sarró S, Pomarol-Clotet E, McKenna P, Hinzen W. Processing of linguistic deixis in people with schizophrenia, with and without auditory verbal hallucinations. Neuroimage Clin. 2022;34:103007. DOI: 10.1016/j.nicl.2022.103007
  • dc.identifier.doi http://dx.doi.org/10.1016/j.nicl.2022.103007
  • dc.identifier.issn 2213-1582
  • dc.identifier.uri http://hdl.handle.net/10230/56230
  • dc.language.iso eng
  • dc.publisher Elsevier
  • dc.relation.ispartof NeuroImage: Clinical. 2022;34:103007.
  • dc.relation.isreferencedby https://ars.els-cdn.com/content/image/1-s2.0-S2213158222000729-mmc1.docx
  • dc.relation.projectID info:eu-repo/grantAgreement/ES/2PE/PID2019-105241GB-I00
  • dc.relation.projectID info:eu-repo/grantAgreement/ES/1PE/FFI2016-77647-C2-2-P
  • dc.rights © 2022 The Authors. Published by Elsevier Inc. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/bync-nd/4.0/).
  • dc.rights.accessRights info:eu-repo/semantics/openAccess
  • dc.rights.uri http://creativecommons.org/licenses/by-nc-nd/4.0/
  • dc.subject.keyword Deixis
  • dc.subject.keyword Language
  • dc.subject.keyword Schizophrenia
  • dc.subject.keyword Auditory verbal hallucinations
  • dc.title Processing of linguistic deixis in people with schizophrenia, with and without auditory verbal hallucinations
  • dc.type info:eu-repo/semantics/article
  • dc.type.version info:eu-repo/semantics/publishedVersion

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