Whole-brain model replicates sleep-like slow-wave dynamics generated by stroke lesions

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  • dc.contributor.author Idesis, Sebastian Ariel
  • dc.contributor.author Patow, Gustavo
  • dc.contributor.author Allegra, Michele
  • dc.contributor.author Vohryzek, Jakub
  • dc.contributor.author Sanz Perl, Yonatan
  • dc.contributor.author Sanchez-Vives, Maria V.
  • dc.contributor.author Massimini, Marcello
  • dc.contributor.author Corbetta, Maurizio
  • dc.contributor.author Deco, Gustavo
  • dc.date.accessioned 2025-06-19T07:25:09Z
  • dc.date.available 2025-06-19T07:25:09Z
  • dc.date.issued 2024
  • dc.description.abstract Focal brain injuries, such as stroke, cause local structural damage as well as alteration of neuronal activity in distant brain regions. Experimental evidence suggests that one of these changes is the appearance of sleep-like slow waves in the otherwise awake individual. This pattern is prominent in areas surrounding the damaged region and can extend to connected brain regions in a way consistent with the individual's specific long-range connectivity patterns. In this paper we present a generative whole-brain model based on (f)MRI data that, in combination with the disconnection mask associated with a given patient, explains the effects of the sleep-like slow waves originated in the vicinity of the lesion area on the distant brain activity. Our model reveals new aspects of their interaction, being able to reproduce functional connectivity patterns of stroke patients and offering a detailed, causal understanding of how stroke-related effects, in particular slow waves, spread throughout the brain. The presented findings demonstrate that the model effectively captures the links between stroke occurrences, sleep-like slow waves, and their subsequent spread across the human brain.
  • dc.description.sponsorship S·I is supported by the project NEurological MEchanismS of Injury, and Sleep-like cellular dynamics (NEMESIS) (ref. 101071900) funded by the EU ERC Synergy Horizon Europe. G.P. is supported by Grant PID2021-122136OB-C22 funded by MCIN/AEI/ 10.13039/501100011033 and by ERDF A way of making Europe. G.D. is supported by 10.13039/50110001103310.13039/501100011033Grant PID2022-136216NB-I00 funded by MICIU/AEI/10.13039/501100011033 and by "ERDF A way of making Europe", "ERDF, EU". MVSV is supported by PID2020-112947RB-I00 AEI /10.13039/501100011033, funded by the Spanish Ministry of Science, Innovation and Universities (MCIU). MC is supported by Fondazione Cassa di Risparmio di Padova e Rovigo (CARIPARO)(GA number 55403); Ministry of Health Italy: NEUROCONN (RF-2008 -12366899); H2020 European School of Network Neuroscience- euSNN, H2020-SC5–2019-2, (Grant Agreement number 869505); Ministry of Health Italy: EYEMOVINSTROKE (RF-2019-12369300).
  • dc.format.mimetype application/pdf
  • dc.identifier.citation Idesis S, Patow G, Allegra M, Vohryzek J, Sanz Perl Y, Sanchez-Vives MV, et al. Whole-brain model replicates sleep-like slow-wave dynamics generated by stroke lesions. Neurobiol Dis. 2024 Oct 1;200:106613. DOI: 10.1016/j.nbd.2024.106613
  • dc.identifier.doi http://dx.doi.org/10.1016/j.nbd.2024.106613
  • dc.identifier.issn 0969-9961
  • dc.identifier.uri http://hdl.handle.net/10230/70726
  • dc.language.iso eng
  • dc.publisher Elsevier
  • dc.relation.ispartof Neurobiology of Disease. 2024 Oct 1;200:106613
  • dc.relation.projectID info:eu-repo/grantAgreement/EC/HE/101071900
  • dc.relation.projectID info:eu-repo/grantAgreement/ES/3PE/PID2021-122136OB-C22
  • dc.relation.projectID info:eu-repo/grantAgreement/ES/3PE/PID2022-136216NB-I00
  • dc.relation.projectID info:eu-repo/grantAgreement/ES/2PE/PID2020-112947RB-I00
  • dc.relation.projectID info:eu-repo/grantAgreement/EC/H2020/869505
  • dc.rights © 2024 The Author(s). Published by Elsevier Inc. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
  • dc.rights.accessRights info:eu-repo/semantics/openAccess
  • dc.rights.uri http://creativecommons.org/licenses/by-nc-nd/4.0/
  • dc.subject.keyword Whole-brain models
  • dc.subject.keyword Predictive
  • dc.subject.keyword Stroke
  • dc.subject.keyword (f)MRI
  • dc.subject.keyword Sleep-like slow waves
  • dc.title Whole-brain model replicates sleep-like slow-wave dynamics generated by stroke lesions
  • dc.type info:eu-repo/semantics/article
  • dc.type.version info:eu-repo/semantics/publishedVersion

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