Whole-brain model replicates sleep-like slow-wave dynamics generated by stroke lesions

Idesis, Sebastian Ariel; Patow, Gustavo; Allegra, Michele; Vohryzek, Jakub; Sanz Perl, Yonatan; Sanchez-Vives, Maria V.; Massimini, Marcello; Corbetta, Maurizio; Deco, Gustavo

doi:http://dx.doi.org/10.1016/j.nbd.2024.106613

Whole-brain model replicates sleep-like slow-wave dynamics generated by stroke lesions

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Idesis S, Patow G, Allegra M, Vohryzek J, Sanz Perl Y, Sanchez-Vives MV, et al. Whole-brain model replicates sleep-like slow-wave dynamics generated by stroke lesions. Neurobiol Dis. 2024 Oct 1;200:106613. DOI: 10.1016/j.nbd.2024.106613

Abstract

Focal brain injuries, such as stroke, cause local structural damage as well as alteration of neuronal activity in distant brain regions. Experimental evidence suggests that one of these changes is the appearance of sleep-like slow waves in the otherwise awake individual. This pattern is prominent in areas surrounding the damaged region and can extend to connected brain regions in a way consistent with the individual's specific long-range connectivity patterns. In this paper we present a generative whole-brain model based on (f)MRI data that, in combination with the disconnection mask associated with a given patient, explains the effects of the sleep-like slow waves originated in the vicinity of the lesion area on the distant brain activity. Our model reveals new aspects of their interaction, being able to reproduce functional connectivity patterns of stroke patients and offering a detailed, causal understanding of how stroke-related effects, in particular slow waves, spread throughout the brain. The presented findings demonstrate that the model effectively captures the links between stroke occurrences, sleep-like slow waves, and their subsequent spread across the human brain.