MicroCT imaging reveals differential 3D micro-scale remodelling of the murine aorta in ageing and Marfan syndrome

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• dc.contributor.author López-Guimet, Júlia
• dc.contributor.author Peña-Pérez, Lucía
• dc.contributor.author Bradley, Robert S.
• dc.contributor.author García-Canadilla, Patricia
• dc.contributor.author Disney, Catherine
• dc.contributor.author Geng, Hua
• dc.contributor.author Bodey, Andrew J.
• dc.contributor.author Withers, Philip J.
• dc.contributor.author Bijnens, Bart
• dc.contributor.author Sherratt, Michael J.
• dc.contributor.author Egea, Gustavo
• dc.date.accessioned 2019-03-25T09:51:35Z
• dc.date.available 2019-03-25T09:51:35Z
• dc.date.issued 2018
• dc.description.abstract Aortic wall remodelling is a key feature of both ageing and genetic connective tissue diseases, which are associated with vasculopathies such as Marfan syndrome (MFS). Although the aorta is a 3D structure, little attention has been paid to volumetric assessment, primarily due to the limitations of conventional imaging techniques. Phase-contrast microCT is an emerging imaging technique, which is able to resolve the 3D micro-scale structure of large samples without the need for staining or sectioning.
• dc.description.sponsorship J.L.-G. is supported by a Spanish Government predoctoral fellowship FPI (BES-2013-065962 and EEBB-I-16-11080), and by a Boehringer Ingelheim Fonds travel grant for her stay at Diamond synchrotron. The Manchester X-Ray Imaging Facility is funded in part by the Engineering and Physical Sciences Research Council [ESPRC] (grant numbers EP/F007906/1, EP/F001452/1 and EP/I02249X/1). This study was supported by grants SAF2015-64136-R and SAF2017-83039-R to G.E., and partially supported by grants TIN2014-52923-R, Maria de Maeztu Units of Excellence Programme/MDM-2015-0502, and FEDER to B.B. The Diamond Manchester collaboration awarded synchrotron beam time to the authors (session ID MT12199-1). C.D. was supported by an EPSRC & MRC Centre for Doctoral Training (CDT) Regenerative Medicine (EP/L014904/1) studentship. P.W. is grateful for a European Research Council grant (Correl-CT grant No 695638). G.E. thanks Damelys Alejandra Fumero for her casual economic contribution to his research.
• dc.format.mimetype application/pdf
• dc.identifier.citation López-Guimet J, Peña-Pérez L, Bradley RS, García-Canadilla P, Disney C, Geng H, Bodey AJ, Withers PJ, Bijnens B, Sherratt MJ, Egea G. MicroCT imaging reveals differential 3D micro-scale remodelling of the murine aorta in ageing and Marfan syndrome. Theranostics. 2018;8(21):6038-52. DOI: 10.7150/thno.26598
• dc.identifier.doi http://dx.doi.org/10.7150/thno.26598
• dc.identifier.issn 1838-7640
• dc.identifier.uri http://hdl.handle.net/10230/36954
• dc.language.iso eng
• dc.publisher Ivyspring International Publisher
• dc.relation.ispartof Theranostics. 2018;8(21):6038-52
• dc.relation.projectID info:eu-repo/grantAgreement/ES/1PE/BES2013-065962
• dc.relation.projectID info:eu-repo/grantAgreement/ES/1PE/SAF2015-64136-R
• dc.relation.projectID info:eu-repo/grantAgreement/ES/2PE/SAF2017-83039-R
• dc.relation.projectID info:eu-repo/grantAgreement/ES/1PE/TIN2014-52923-R
• dc.relation.projectID info:eu-repo/grantAgreement/EC/H2020/695638
• dc.rights © The authors. This is an open access article distributed under the terms of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). See http://ivyspring.com/terms for full terms and conditions.
• dc.rights.accessRights info:eu-repo/semantics/openAccess
• dc.rights.uri https://creativecommons.org/licenses/by/4.0/
• dc.subject.keyword Marfan syndrome
• dc.subject.keyword MicroCT
• dc.subject.keyword Aorta
• dc.subject.keyword Ageing
• dc.subject.keyword Elastic lamella
• dc.title MicroCT imaging reveals differential 3D micro-scale remodelling of the murine aorta in ageing and Marfan syndrome
• dc.type info:eu-repo/semantics/article
• dc.type.version info:eu-repo/semantics/publishedVersion