MicroCT imaging reveals differential 3D micro-scale remodelling of the murine aorta in ageing and Marfan syndrome

López-Guimet, Júlia; Peña-Pérez, Lucía; Bradley, Robert S.; García-Canadilla, Patricia; Disney, Catherine; Geng, Hua; Bodey, Andrew J.; Withers, Philip J.; Bijnens, Bart; Sherratt, Michael J.; Egea, Gustavo

doi:http://dx.doi.org/10.7150/thno.26598

MicroCT imaging reveals differential 3D micro-scale remodelling of the murine aorta in ageing and Marfan syndrome

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López-Guimet J, Peña-Pérez L, Bradley RS, García-Canadilla P, Disney C, Geng H, Bodey AJ, Withers PJ, Bijnens B, Sherratt MJ, Egea G. MicroCT imaging reveals differential 3D micro-scale remodelling of the murine aorta in ageing and Marfan syndrome. Theranostics. 2018;8(21):6038-52. DOI: 10.7150/thno.26598

Abstract

Aortic wall remodelling is a key feature of both ageing and genetic connective tissue diseases, which are associated with vasculopathies such as Marfan syndrome (MFS). Although the aorta is a 3D structure, little attention has been paid to volumetric assessment, primarily due to the limitations of conventional imaging techniques. Phase-contrast microCT is an emerging imaging technique, which is able to resolve the 3D micro-scale structure of large samples without the need for staining or sectioning.