In-silico analysis of the influence of pulmonary vein configuration on left atrial haemodynamics and thrombus formation in a large cohort

Mostra el registre complet Registre parcial de l'ítem

• dc.contributor.author Mill, Jordi
• dc.contributor.author Harrison, Josquin
• dc.contributor.author Legghe, Benoit
• dc.contributor.author Olivares, Andy L.
• dc.contributor.author Morales, Xabier
• dc.contributor.author Noailly, Jérôme
• dc.contributor.author Iriart, Xavier
• dc.contributor.author Cochet, Hubert
• dc.contributor.author Sermesant, Maxime
• dc.contributor.author Camara, Oscar
• dc.date.accessioned 2022-10-18T15:21:56Z
• dc.date.available 2022-10-18T15:21:56Z
• dc.date.issued 2021
• dc.description Comunicació presentada a: FIMH 2021 11th International Conference, celebrada del 21 al 25 de juny de 2021 a Stanford, CA, USA.
• dc.description.abstract Atrial fibrillation (AF) is considered the most common human arrhythmia. Around 99% of thrombi in non-valvular AF are formed in the left atrial appendage (LAA). Studies suggest that abnormal LAA haemodynamics and the subsequently stagnated flow are the factors triggering clot formation. However, the relation between LAA morphology, the blood pattern and the triggering is not fully understood. Moreover, the impact of structures such as the pulmonary veins (PVs) on LA haemodynamics has not been thoroughly studied due to the difficulties of acquiring appropriate data. On the other hand, in-silico studies and flow simulations allow a thorough analysis of haemodynamics, analysing the 4D nature of blood flow patterns under different boundary conditions. However, the reduced number of cases reported on the literature of these studies has been a limitation. The main goal of this work was to study the influence of PVs on left atrium (LA) and LAA haemodynamics. Computational fluid dynamics simulations were run on 52 patients, the largest cohort so far in the literature, where different parameters were individually studied: pulmonary veins orientation and configuration; LAA and LA volumes and its ratio; and flow velocities. Our computational analysis showed how the right pulmonary vein height and angulation have a great influence on LA haemodynamics. Additionally, we found that LAA with great bending with its tip pointing towards the mitral valve could contribute to favour flow stagnation.en
• dc.description.sponsorship This work was supported by the Agency for Management of University and Research Grants of the Generalitat de Catalunya under the the Grants for the Contracting of New Research Staff Programme - FI (2020 FI B 00608) and the Spanish Ministry of Economy and Competitiveness under the Programme for the Formation of Doctors (PRE2018-084062), the Maria de Maeztu Units of Excellence Programme (MDM-2015-0502) and the Retos Investigaci´on project (RTI2018-101193-B-I00). Additionally, this work was supported by the H2020 EU SimCardioTest project (Digital transformation in Health and Care SC1- DTH-06-2020; grant agreement No. 101016496) and the European project PARIS (ID35).en
• dc.format.mimetype application/pdf
• dc.identifier.citation Mill J, Harrison J, Legghe B, Olivares AL, Morales X, Noailly J, Iriart X, Cochet H, Sermesant M, Camara O. In-silico analysis of the influence of pulmonary vein configuration on left atrial haemodynamics and thrombus formation in a large cohort. In: Ennis DB, Perotti LE, Wang VY, editors. Functional Imaging and Modeling of the Heart. 11th International Conference, FIMH 2021; 2021 Jun 21-25; Stanford, USA. Cham: Springer; 2021. p. 605-16. (LNCS; no. 12738). DOI: 10.1007/978-3-030-78710-3_58
• dc.identifier.doi http://doi.org/10.1007/978-3-030-78710-3_58
• dc.identifier.isbn 9783030787103
• dc.identifier.issn 0302-9743
• dc.identifier.uri http://hdl.handle.net/10230/54474
• dc.language.iso eng
• dc.publisher Springer
• dc.relation.ispartof Ennis DB, Perotti LE, Wang VY, editors. Functional Imaging and Modeling of the Heart. 11th International Conference, FIMH 2021; 2021 Jun 21-25; Stanford, USA. Cham: Springer; 2021. p. 605-16. (LNCS; no. 12738).
• dc.relation.projectID info:eu-repo/grantAgreement/ES/2PE/PRE2018-084062
• dc.relation.projectID info:eu-repo/grantAgreement/EC/H2020/101016496
• dc.relation.projectID info:eu-repo/grantAgreement/ES/2PE/RTI2018-101193-B-I00
• dc.rights © Springer The final publication is available at Springer via http://dx.doi.org/10.1007/978-3-030-78710-3_58
• dc.rights.accessRights info:eu-repo/semantics/openAccess
• dc.subject.keyword Pulmonary veinsen
• dc.subject.keyword Computational fluid dynamicsen
• dc.subject.keyword Left atrium haemodynamicsen
• dc.subject.keyword Thrombus formationen
• dc.title In-silico analysis of the influence of pulmonary vein configuration on left atrial haemodynamics and thrombus formation in a large cohort
• dc.type info:eu-repo/semantics/conferenceObject
• dc.type.version info:eu-repo/semantics/acceptedVersion