• Regulation of T cell fates by the transcription factor NFAT5 in different microenvironments

  Alberdi Ibarzabal, Maria, 1986- (Universitat Pompeu Fabra, 2015-07-24)

  CD4+ T cells can adopt specific functional programs in response to changes in microenvironment variables, such as cytokine availability, cell-to-cell contacts and stress conditions. It has been described that the elevation ...
• Identification of genetic modifiers of penetrance in human inherited disease

  Puigdevall Costa, Pau, 1991- (Universitat Pompeu Fabra, 2019-01-17)

  Understanding the molecular basis of human inherited disease is a challenging task due to the complexity of mapping the genotype to the phenotype. The study of diseases running in families has shown that the inheritance ...
• Non-vertical genomics in fungal evolution

  Naranjo Ortiz, Miguel Ángel, 1989- (Universitat Pompeu Fabra, 2019-01-18)

  Non-vertical genomic events, which include horizontal gene transfer (HGT) and hybridization, are widely studied evolutionary processes in certain groups. HGT is particularly well known for prokaryotic organisms, while ...
• Computationl and modeling approaches to multi-scale anatomical description of neuronal circuitry

  Manubens-Gil, Linus, 1989- (Universitat Pompeu Fabra, 2018-01-18)

  During the last century the nervous system has been mainly studied from a reductionistic approach, based on the hypothesis that understanding in depth single neurons or limited neuronal populations would lead to general ...
• Development of model systems to reconstruct the unicellular prehistory of animals : an emphasis on the cell cycle

  Pérez-Posada, Alberto, 1993- (Universitat Pompeu Fabra, 2019-12-16)

  El origen de la multicelularidad animal tiene sus raíces en el proceso de división celular. Conocer las bases moleculares del control de la divisón celular en animales y en sus parientes unicelulares tiene el potencial de ...
• Exploring the role of DYRK1A in RNA polymerase III transcription : DYRK1A as a potential regulator of TFIIIC

  Cort, Rianne Angelica, 1991- (Universitat Pompeu Fabra, 2019-12-13)

  The kinase DYRK1A (dual-specificity tyrosine-regulated kinase 1A) is a dosage-sensitive gene, since both haploinsufficiency and overexpression when in trisomy lead to pathological phenotypes in humans. In this Thesis, the ...
• ¿Numerus clausus? : crítica al sistema de incriminación de los delitos de las personas jurídicas

  Vargas Ovalle, María Alejandra (Universitat Pompeu Fabra, 2018-01-12)

  El Código penal español reconoce desde 2010 la responsabilidad penal de las personas jurídicas, aunque limitada a un catálogo cerrado de delitos. La configuración del sistema de numerus clausus -como sucede con la práctica ...
• Towards improving lymphangioleiomyomatosis care : a study of biomarkers and therapies

  Herranz Ors, Carmen, 1992- (Universitat Pompeu Fabra, 2019-12-16)

  LAM is a rare metastasizing and destructive disorder of the lung. The disease is caused by cells carrying mutations in the TSC1/2 genes, but the tissue of origin of diseased cells remains unknown. The standard of care for ...
• Focused transhepatic electroporation mediated by hypersaline infusion through the portal vein in murine model : Preliminary results on differential conductivity and safety

  Pañella Vilamú, Clara, 1987- (Universitat Pompeu Fabra, 2019-12-19)

  INTRODUCCIÓN: Este estudio evalúa el aumento selectivo de la conductividad hepática mediante la infusión hipersalina en el sistema portomesentérico para tratar simultáneamente todos los tumores hepáticos mediante electroporación ...
• Managing compliance in a multi-level polity: the case of the European Union

  Clinton, Peter (Universitat Pompeu Fabra, 2019-12-17)

  This thesis tackles the issue of non-compliance in the European Union (EU). This is an important issue because without Member State (MS) compliance with EU policy outputs, collective policy goals may not be achieved. ...
• Changing paradigms of women's labor market participation: cases of Denmark and the USA

  Ratniece, Luïze (Universitat Pompeu Fabra, 2019-12-16)

  This thesis contributes to knowledge about gender differences in labor market attachment by using a longitudinal, life-course approach, and consists of three empirical articles. The first one establishes the profile of ...
• Streamlining minimal bacterial genomes : Analysis of the pan bacterial essential genome, and a novel strategy for random genome deletions in Mycoplasma pneumoniae

  Shaw, Daniel, 1993- (Universitat Pompeu Fabra, 2019-12-13)

  Understanding what constitutes a true Minimal Cell is a key challenge in synthetic biology. In this work, we present two new tools to aid in this endeavour. i) A novel methodology for minimising the Mycoplasma pneumoniae ...
• Genetic structure of North African human populations : A complex history of admixture

  Rubio Araúna, Lara, 1990- (Universitat Pompeu Fabra, 2017-12-14)

  North African populations show a complex genetic structure characterized by the admixture of at least four different components: Middle Eastern, sub-Saharan, European and autochthonous North African. However, there are few ...
• La Visió infantil a Catalunya

  Vila i Vidal, Núria, 1967- (Universitat Pompeu Fabra, 2019-11-08)

  La visió té una importància crucial per als infants a l’hora de desenvolupar-se i en l’àmbit escolar. Malgrat aquesta importància, no hi ha dades poblacionals de visió infantil a Catalunya, cosa que dificulta l’elaboració ...
• La Competencia interaccional de estudiantes de ELE: gestión de turnos en actividades de interacción oral

  Acosta Ortega, Laura (Universitat Pompeu Fabra, 2019-12-18)

  Muchos son los estudios que se han ocupado de estudiar las interacciones orales en primeras lenguas y en algunas lenguas adicionales. Sin embargo, son menos los trabajos empíricos que se ocupan de cómo se gestionan las ...
• Neurobiological correlates of behavioural alterations in mouse models of MBNL2 deficiNeurobiological correlates of behavioural alterations in mouse models of MBNL2 deficiency and pharmacological interventions : relevance for myotonic dystrophy type 1 for myotonic dystrophy type 1

  Ramon Duaso, Carla, 1987- (Universitat Pompeu Fabra, 2019-12-16)

  Myotonic dystrophy type 1 (DM1) is a rare disease characterized by muscular defects, as well as, cognitive and mood alterations. Although these neurophysiological disturbances are very debilitating, there is lack of data ...
• Molecular mechanisms of msl2 mRNA translational regulation

  García Beyaert, Marina, 1983- (Universitat Pompeu Fabra, 2016-01-27)

  Regulation of msl2 translation is a key step in the modulation of X-chromosome dosage compensation. MSL2 is the limiting subunit of the dosage compensation complex, an assembly that promotes hyper-transcription of the ...
• Big data, poder y libertad : sobre el impacto social y político de la vigilancia mas

  Suárez Gonzalo, Sara (Universitat Pompeu Fabra, 2019-12-16)

  Esta tesis doctoral reflexiona sobre el impacto social y político de la explotación de datos masivos a nivel europeo. Cumple dos objetivos principales. En primer lugar, define el contexto general en el que se produce esta ...
• Disorderly speech in audiovisual fiction and its translation : portrayals of characters under the influence of alcohol and drugs

  Parra López, Guillermo (Universitat Pompeu Fabra, 2019-12-16)

  Much research has been conducted on language variation and marked speech in its various forms, such as dialects, registers, and styles. There is one variety, however, which seems to have been broadly overlooked in translation ...
• Celuloide inaudito: prácticas sonoras en el cine estructural (1960-1981)

  Viñas Alcoz, Albert (Universitat Pompeu Fabra, 2016-01-14)

  Esta tesis estudia el sonido del cine estructural analizando sus fundamentaciones teóricas, sus tratamientos prácticos y sus apreciaciones estéticas. Se parte de una serie de películas estructurales internacionales englobadas ...

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