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Sensitivity analysis of geometrical parameters to study haemodynamics and thrombus formation in the left atrial appendage

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dc.contributor.author García-Isla, Guadalupe
dc.contributor.author Olivares Miyares, Andy Luis
dc.contributor.author Silva, Etelvino
dc.contributor.author Nuñez-Garcia, Marta
dc.contributor.author Butakoff, Constantine
dc.contributor.author Sanchez-Quintana, Damian
dc.contributor.author Morales, Hernán G.
dc.contributor.author Freixa, Xavier
dc.contributor.author Noailly, Jérôme
dc.contributor.author De Potter, Tom
dc.contributor.author Camara, Oscar
dc.date.accessioned 2021-07-22T11:02:21Z
dc.date.available 2021-07-22T11:02:21Z
dc.date.issued 2018
dc.identifier.citation García-Isla G, Olivares AL, Silva E, Nuñez-Garcia M, Butakoff C, Sanchez-Quintana D, Morales HG, Freixa X, Noailly J, De Potter T, Camara O. Sensitivity analysis of geometrical parameters to study haemodynamics and thrombus formation in the left atrial appendage. Int J Numer Method Biomed Eng. 2018;34(8):e3100. DOI: 10.1002/cnm.3100
dc.identifier.issn 2040-7939
dc.identifier.uri http://hdl.handle.net/10230/48278
dc.description.abstract The left atrial appendage (LAA) is a complex and heterogeneous protruding structure of the left atrium (LA). In atrial fibrillation patients, it is the location where 90% of the thrombi are formed. However, the role of the LAA in thrombus formation is not fully known yet. The main goal of this work is to perform a sensitivity analysis to identify the most relevant LA and LAA morphological parameters in atrial blood flow dynamics. Simulations were run on synthetic ellipsoidal left atria models where different parameters were individually studied: pulmonary veins and mitral valve dimensions; LAA shape; and LA volume. Our computational analysis confirmed the relation between large LAA ostia, low blood flow velocities and thrombus formation. Additionally, we found that pulmonary vein configuration exerted a critical influence on LAA blood flow patterns. These findings contribute to a better understanding of the LAA and to support clinical decisions for atrial fibrillation patients.
dc.description.sponsorship This work was partly supported by COMPILAAO Retos I+D project (DPI2015-71640-R) and the Fundacio La Marato de TV3 (20154031).
dc.format.mimetype application/pdf
dc.language.iso eng
dc.publisher Wiley
dc.relation.ispartof International Journal for Numerical Methods in Biomedical Engineering. 2018;34(8):e3100
dc.rights This is the peer reviewed version of the following article: García-Isla G, Olivares AL, Silva E, Nuñez-Garcia M, Butakoff C, Sanchez-Quintana D, Morales HG, Freixa X, Noailly J, De Potter T, Camara O. Sensitivity analysis of geometrical parameters to study haemodynamics and thrombus formation in the left atrial appendage. Int J Numer Method Biomed Eng. 2018;34(8):e3100., which has been published in final form at http://dx.doi.org/10.1002/cnm.3100. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions.
dc.title Sensitivity analysis of geometrical parameters to study haemodynamics and thrombus formation in the left atrial appendage
dc.type info:eu-repo/semantics/article
dc.identifier.doi http://dx.doi.org/10.1002/cnm.3100
dc.subject.keyword Computational fluid dynamics
dc.subject.keyword Haemodynamics patterns
dc.subject.keyword Left atrial appendage morphology
dc.subject.keyword Sensitivity analysis
dc.subject.keyword Thrombus formation
dc.relation.projectID info:eu-repo/grantAgreement/ES/1PE/DPI2015-71640-R
dc.rights.accessRights info:eu-repo/semantics/openAccess
dc.type.version info:eu-repo/semantics/acceptedVersion

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