Sensitivity analysis of geometrical parameters to study haemodynamics and thrombus formation in the left atrial appendage

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• dc.contributor.author García-Isla, Guadalupe
• dc.contributor.author Olivares Miyares, Andy Luis
• dc.contributor.author Silva, Etelvino
• dc.contributor.author Nuñez-Garcia, Marta
• dc.contributor.author Butakoff, Constantine
• dc.contributor.author Sanchez-Quintana, Damian
• dc.contributor.author Morales, Hernán G.
• dc.contributor.author Freixa, Xavier
• dc.contributor.author Noailly, Jérôme
• dc.contributor.author De Potter, Tom
• dc.contributor.author Camara, Oscar
• dc.date.accessioned 2021-07-22T11:02:21Z
• dc.date.available 2021-07-22T11:02:21Z
• dc.date.issued 2018
• dc.description.abstract The left atrial appendage (LAA) is a complex and heterogeneous protruding structure of the left atrium (LA). In atrial fibrillation patients, it is the location where 90% of the thrombi are formed. However, the role of the LAA in thrombus formation is not fully known yet. The main goal of this work is to perform a sensitivity analysis to identify the most relevant LA and LAA morphological parameters in atrial blood flow dynamics. Simulations were run on synthetic ellipsoidal left atria models where different parameters were individually studied: pulmonary veins and mitral valve dimensions; LAA shape; and LA volume. Our computational analysis confirmed the relation between large LAA ostia, low blood flow velocities and thrombus formation. Additionally, we found that pulmonary vein configuration exerted a critical influence on LAA blood flow patterns. These findings contribute to a better understanding of the LAA and to support clinical decisions for atrial fibrillation patients.
• dc.description.sponsorship This work was partly supported by COMPILAAO Retos I+D project (DPI2015-71640-R) and the Fundacio La Marato de TV3 (20154031).
• dc.format.mimetype application/pdf
• dc.identifier.citation García-Isla G, Olivares AL, Silva E, Nuñez-Garcia M, Butakoff C, Sanchez-Quintana D, Morales HG, Freixa X, Noailly J, De Potter T, Camara O. Sensitivity analysis of geometrical parameters to study haemodynamics and thrombus formation in the left atrial appendage. Int J Numer Method Biomed Eng. 2018;34(8):e3100. DOI: 10.1002/cnm.3100
• dc.identifier.doi http://dx.doi.org/10.1002/cnm.3100
• dc.identifier.issn 2040-7939
• dc.identifier.uri http://hdl.handle.net/10230/48278
• dc.language.iso eng
• dc.publisher Wiley
• dc.relation.ispartof International Journal for Numerical Methods in Biomedical Engineering. 2018;34(8):e3100
• dc.relation.projectID info:eu-repo/grantAgreement/ES/1PE/DPI2015-71640-R
• dc.rights This is the peer reviewed version of the following article: García-Isla G, Olivares AL, Silva E, Nuñez-Garcia M, Butakoff C, Sanchez-Quintana D, Morales HG, Freixa X, Noailly J, De Potter T, Camara O. Sensitivity analysis of geometrical parameters to study haemodynamics and thrombus formation in the left atrial appendage. Int J Numer Method Biomed Eng. 2018;34(8):e3100., which has been published in final form at http://dx.doi.org/10.1002/cnm.3100. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions.
• dc.rights.accessRights info:eu-repo/semantics/openAccess
• dc.subject.keyword Computational fluid dynamics
• dc.subject.keyword Haemodynamics patterns
• dc.subject.keyword Left atrial appendage morphology
• dc.subject.keyword Sensitivity analysis
• dc.subject.keyword Thrombus formation
• dc.title Sensitivity analysis of geometrical parameters to study haemodynamics and thrombus formation in the left atrial appendage
• dc.type info:eu-repo/semantics/article
• dc.type.version info:eu-repo/semantics/acceptedVersion