Welcome to the UPF Digital Repository

Focused transhepatic electroporation mediated by hypersaline infusion through the portal vein in rat model: Preliminary results on differential conductivity

Show simple item record

dc.contributor.author Pañella Vilamú, Clara, 1987-
dc.contributor.author Castellví Fernández, Quim
dc.contributor.author Moll, Xavier
dc.contributor.author Quesada Diez, Rita
dc.contributor.author Villanueva, Alberto
dc.contributor.author Iglesias, Mar
dc.contributor.author Naranjo‐Hans, Dolores
dc.contributor.author Sánchez Velázquez, Patricia, 1985-
dc.contributor.author Andaluz, Anna
dc.contributor.author Grande Posa, Luís
dc.contributor.author Ivorra Cano, Antoni, 1974-
dc.contributor.author Burdío Pinilla, Fernando
dc.date.accessioned 2021-06-10T07:16:32Z
dc.date.available 2021-06-10T07:16:32Z
dc.date.issued 2017
dc.identifier.citation Pañella C, Castellví Q, Moll X, Quesada R, Villanueva A, Iglesias M, Naranjo D, Sánchez-Velázquez P, Andaluz A, Grande L, Ivorra A, Burdío F. Focused transhepatic electroporation mediated by hypersaline infusion through the portal vein in rat model: Preliminary results on differential conductivity. Radiol Oncol. 2017;51(4):415-21. DOI: 10.1515/raon-2017-0051
dc.identifier.issn 1318-2099
dc.identifier.uri http://hdl.handle.net/10230/47837
dc.description.abstract Background. Spread hepatic tumours are not suitable for treatment either by surgery or conventional ablation methods. The aim of this study was to evaluate feasibility and safety of selectively increasing the healthy hepatic conductivity by the hypersaline infusion (HI) through the portal vein. We hypothesize this will allow simultaneous safe treatment of all nodules by irreversible electroporation (IRE) when applied in a transhepatic fashion. Material and methods. Sprague Dawley (Group A, n = 10) and Athymic rats with implanted hepatic tumour (Group B, n = 8) were employed. HI was performed (NaCl 20%, 3.8 mL/Kg) by trans-splenic puncture. Deionized serum (40 mL/Kg) and furosemide (2 mL/Kg) were simultaneously infused through the jugular vein to compensate hypernatremia. Changes in conductivity were monitored in the hepatic and tumour tissue. The period in which hepatic conductivity was higher than tumour conductivity was defined as the therapeutic window (TW). Animals were monitored during 1-month follow-up. The animals were sacrificed and selective samples were used for histological analysis. Results. The overall survival rate was 82.4% after the HI protocol. The mean maximum hepatic conductivity after HI was 2.7 and 3.5 times higher than the baseline value, in group A and B, respectively. The mean maximum hepatic conductivity after HI was 1.4 times higher than tumour tissue in group B creating a TW to implement selective IRE. Conclusions. HI through the portal vein is safe when the hypersaline overload is compensated with deionized serum and it may provide a TW for focused IRE treatment on tumour nodules.
dc.description.sponsorship This work received financial support from the Spanish Government (Ministry of Economy and Competitiveness) under Grant TEC2014-52383-C3. The authors disclose no conflicts of interests.
dc.format.mimetype application/pdf
dc.language.iso eng
dc.publisher De Gruyter
dc.relation.ispartof Radiology and Oncology. 2017;51(4):415-21
dc.rights © De Gruyter Published version available at http://dx.doi.org/10.1515/raon-2017-0051 https://creativecommons.org/licenses/by-nc-nd/4.0/
dc.rights.uri https://creativecommons.org/licenses/by-nc-nd/4.0/
dc.title Focused transhepatic electroporation mediated by hypersaline infusion through the portal vein in rat model: Preliminary results on differential conductivity
dc.type info:eu-repo/semantics/article
dc.identifier.doi http://dx.doi.org/10.1515/raon-2017-0051
dc.subject.keyword Irreversible electroporation
dc.subject.keyword Liver tumour
dc.subject.keyword Electrical conductivity
dc.relation.projectID info:eu-repo/grantAgreement/ES/1PE/TEC2014-52383-C3
dc.rights.accessRights info:eu-repo/semantics/openAccess
dc.type.version info:eu-repo/semantics/publishedVersion

Thumbnail

This item appears in the following Collection(s)

Show simple item record

Search DSpace


Advanced Search

Browse

My Account

Statistics

Compliant to Partaking