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Remodeling of the cardiovascular circulation in fetuses of mothers with diabetes: a fetal computational model analysis

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dc.contributor.author Kulkami, Aparna
dc.contributor.author Garcia Canadilla, Patricia
dc.contributor.author Khan, Abdullah
dc.contributor.author Lorenzo, Jose Miguel
dc.contributor.author Beckerman, Karen
dc.contributor.author Valenzuela Alcaraz, Brenda
dc.contributor.author Cruz-Lemini, Mónica
dc.contributor.author Gomez, Olga
dc.contributor.author Gratacós Solsona, Eduard
dc.contributor.author Crispi Brillas, Fàtima
dc.contributor.author Bijnens, Bart
dc.date.accessioned 2019-03-27T09:24:32Z
dc.date.available 2019-03-27T09:24:32Z
dc.date.issued 2018
dc.identifier.citation Kulkarni A, Garcia–Cañadilla P, Khan A, Lorenzo JM, Beckerman K, Valenzuela-Alcaraz B, Cruz-Lemini M, Gomez O, Gratacos E, Crispi F, Bijnens B. Remodeling of the cardiovascular circulation in fetuses of mothers with diabetes: a fetal computational model analysis. Placenta. 2018 Mar;63:1-6. DOI: 10.1016/j.placenta.2017.12.020
dc.identifier.issn 0143-4004
dc.identifier.uri http://hdl.handle.net/10230/36984
dc.description.abstract Myocardial structural and functional abnormalities are known to occur in fetuses of mothers with diabetes mellitus (FMDM). The main aim of this investigation was to explore the cardiovascular circulatory patterns in FMDM using a validated lumped computational model of the cardiovascular system. This was a multi-institutional study involving FMDM compared to fetuses of maternal controls (FC). Fetal echocardiographic Doppler data from left and right ventricular outflow tracts, aortic isthmus, middle cerebral and umbilical arteries were fitted into a validated fetal circulation computational model to estimate patient-specific placental and vascular properties. Non-parametric comparisons were made between resistances, compliances and flows in the brain and placenta in FMDM and FC.
dc.description.sponsorship The funders had no role in study design; in the collection, analysis and interpretation of data; in the writing of the report; and in the decision to submit the article for publication. This study was partly supported by Ministerio de Economia y Competitividad (TIN2014-52923-R); Instituto de Salud Carlos III (PI11/01709, PI12/00801, PI14/00226, PI15/00263; PI15/00130) integrados en el Plan Nacional de I + D + I y cofinanciados por el ISCIII-Subdirección General de Evaluación y el Fondo Europeo de Desarrollo Regional (FEDER) “Otra manera de hacer Europa”; the EU-FP7 for research, technological development and demonstration under grant agreement VP2HF (no611823); The Cerebra Foundation for the Brain Injured Child (Carmarthen, UK); AGAUR 2014 SGR grant nº 928; additionally the research leading to these results has received funding from “la Caixa” Foundation. P.G.C. was supported by the Programa de Ayudas Predoctorales de Formación en investigación en Salud (FI12/00362) from the Instituto Carlos III, Spain. B.V.A. was supported by Programa de Ayudas Postdoctorales from Agència de Gestió d'Ajuts Universitaris i de Recerca [grant number: 2013FI_B 00667].
dc.format.mimetype application/pdf
dc.language.iso eng
dc.publisher Elsevier
dc.relation.ispartof Placenta. 2018 Mar;63:1-6
dc.rights © Elsevier http://dx.doi.org/10.1016/j.placenta.2017.12.020
dc.title Remodeling of the cardiovascular circulation in fetuses of mothers with diabetes: a fetal computational model analysis
dc.type info:eu-repo/semantics/article
dc.identifier.doi http://dx.doi.org/10.1016/j.placenta.2017.12.020
dc.subject.keyword Fetus
dc.subject.keyword Mothers with diabetes mellitus
dc.subject.keyword Computational model
dc.subject.keyword Resistance
dc.subject.keyword Compliance
dc.relation.projectID info:eu-repo/grantAgreement/ES/1PE/TIN2014-52923-R
dc.relation.projectID info:eu-repo/grantAgreement/EC/FP7/611823
dc.rights.accessRights info:eu-repo/semantics/openAccess
dc.type.version info:eu-repo/semantics/acceptedVersion


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