Remodeling of the cardiovascular circulation in fetuses of mothers with diabetes: a fetal computational model analysis
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- dc.contributor.author Kulkami, Aparna
- dc.contributor.author Garcia Canadilla, Patricia
- dc.contributor.author Khan, Abdullah
- dc.contributor.author Lorenzo, Jose Miguel
- dc.contributor.author Beckerman, Karen
- dc.contributor.author Valenzuela Alcaraz, Brenda
- dc.contributor.author Cruz-Lemini, Mónica
- dc.contributor.author Gomez, Olga
- dc.contributor.author Gratacós Solsona, Eduard
- dc.contributor.author Crispi Brillas, Fàtima
- dc.contributor.author Bijnens, Bart
- dc.date.accessioned 2019-03-27T09:24:32Z
- dc.date.available 2019-03-27T09:24:32Z
- dc.date.issued 2018
- dc.description.abstract Myocardial structural and functional abnormalities are known to occur in fetuses of mothers with diabetes mellitus (FMDM). The main aim of this investigation was to explore the cardiovascular circulatory patterns in FMDM using a validated lumped computational model of the cardiovascular system. This was a multi-institutional study involving FMDM compared to fetuses of maternal controls (FC). Fetal echocardiographic Doppler data from left and right ventricular outflow tracts, aortic isthmus, middle cerebral and umbilical arteries were fitted into a validated fetal circulation computational model to estimate patient-specific placental and vascular properties. Non-parametric comparisons were made between resistances, compliances and flows in the brain and placenta in FMDM and FC.
- dc.description.sponsorship The funders had no role in study design; in the collection, analysis and interpretation of data; in the writing of the report; and in the decision to submit the article for publication. This study was partly supported by Ministerio de Economia y Competitividad (TIN2014-52923-R); Instituto de Salud Carlos III (PI11/01709, PI12/00801, PI14/00226, PI15/00263; PI15/00130) integrados en el Plan Nacional de I + D + I y cofinanciados por el ISCIII-Subdirección General de Evaluación y el Fondo Europeo de Desarrollo Regional (FEDER) “Otra manera de hacer Europa”; the EU-FP7 for research, technological development and demonstration under grant agreement VP2HF (no611823); The Cerebra Foundation for the Brain Injured Child (Carmarthen, UK); AGAUR 2014 SGR grant nº 928; additionally the research leading to these results has received funding from “la Caixa” Foundation. P.G.C. was supported by the Programa de Ayudas Predoctorales de Formación en investigación en Salud (FI12/00362) from the Instituto Carlos III, Spain. B.V.A. was supported by Programa de Ayudas Postdoctorales from Agència de Gestió d'Ajuts Universitaris i de Recerca [grant number: 2013FI_B 00667].
- dc.format.mimetype application/pdf
- dc.identifier.citation Kulkarni A, Garcia–Cañadilla P, Khan A, Lorenzo JM, Beckerman K, Valenzuela-Alcaraz B, Cruz-Lemini M, Gomez O, Gratacos E, Crispi F, Bijnens B. Remodeling of the cardiovascular circulation in fetuses of mothers with diabetes: a fetal computational model analysis. Placenta. 2018 Mar;63:1-6. DOI: 10.1016/j.placenta.2017.12.020
- dc.identifier.doi http://dx.doi.org/10.1016/j.placenta.2017.12.020
- dc.identifier.issn 0143-4004
- dc.identifier.uri http://hdl.handle.net/10230/36984
- dc.language.iso eng
- dc.publisher Elsevier
- dc.relation.ispartof Placenta. 2018 Mar;63:1-6
- dc.relation.projectID info:eu-repo/grantAgreement/ES/1PE/TIN2014-52923-R
- dc.relation.projectID info:eu-repo/grantAgreement/EC/FP7/611823
- dc.rights © Elsevier http://dx.doi.org/10.1016/j.placenta.2017.12.020
- dc.rights.accessRights info:eu-repo/semantics/openAccess
- dc.subject.keyword Fetus
- dc.subject.keyword Mothers with diabetes mellitus
- dc.subject.keyword Computational model
- dc.subject.keyword Resistance
- dc.subject.keyword Compliance
- dc.title Remodeling of the cardiovascular circulation in fetuses of mothers with diabetes: a fetal computational model analysis
- dc.type info:eu-repo/semantics/article
- dc.type.version info:eu-repo/semantics/acceptedVersion