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dc.contributor.author | López-Guimet, Júlia |
dc.contributor.author | Peña-Pérez, Lucía |
dc.contributor.author | Bradley, Robert S. |
dc.contributor.author | García-Canadilla, Patricia |
dc.contributor.author | Disney, Catherine |
dc.contributor.author | Geng, Hua |
dc.contributor.author | Bodey, Andrew J. |
dc.contributor.author | Withers, Philip J. |
dc.contributor.author | Bijnens, Bart |
dc.contributor.author | Sherratt, Michael J. |
dc.contributor.author | Egea, Gustavo |
dc.date.accessioned | 2019-03-25T09:51:35Z |
dc.date.available | 2019-03-25T09:51:35Z |
dc.date.issued | 2018 |
dc.identifier.citation | López-Guimet J, Peña-Pérez L, Bradley RS, García-Canadilla P, Disney C, Geng H, Bodey AJ, Withers PJ, Bijnens B, Sherratt MJ, Egea G. MicroCT imaging reveals differential 3D micro-scale remodelling of the murine aorta in ageing and Marfan syndrome. Theranostics. 2018;8(21):6038-52. DOI: 10.7150/thno.26598 |
dc.identifier.issn | 1838-7640 |
dc.identifier.uri | http://hdl.handle.net/10230/36954 |
dc.description.abstract | Aortic wall remodelling is a key feature of both ageing and genetic connective tissue diseases, which are associated with vasculopathies such as Marfan syndrome (MFS). Although the aorta is a 3D structure, little attention has been paid to volumetric assessment, primarily due to the limitations of conventional imaging techniques. Phase-contrast microCT is an emerging imaging technique, which is able to resolve the 3D micro-scale structure of large samples without the need for staining or sectioning. |
dc.description.sponsorship | J.L.-G. is supported by a Spanish Government predoctoral fellowship FPI (BES-2013-065962 and EEBB-I-16-11080), and by a Boehringer Ingelheim Fonds travel grant for her stay at Diamond synchrotron. The Manchester X-Ray Imaging Facility is funded in part by the Engineering and Physical Sciences Research Council [ESPRC] (grant numbers EP/F007906/1, EP/F001452/1 and EP/I02249X/1). This study was supported by grants SAF2015-64136-R and SAF2017-83039-R to G.E., and partially supported by grants TIN2014-52923-R, Maria de Maeztu Units of Excellence Programme/MDM-2015-0502, and FEDER to B.B. The Diamond Manchester collaboration awarded synchrotron beam time to the authors (session ID MT12199-1). C.D. was supported by an EPSRC & MRC Centre for Doctoral Training (CDT) Regenerative Medicine (EP/L014904/1) studentship. P.W. is grateful for a European Research Council grant (Correl-CT grant No 695638). G.E. thanks Damelys Alejandra Fumero for her casual economic contribution to his research. |
dc.format.mimetype | application/pdf |
dc.language.iso | eng |
dc.publisher | Ivyspring International Publisher |
dc.relation.ispartof | Theranostics. 2018;8(21):6038-52 |
dc.rights | © The authors. This is an open access article distributed under the terms of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). See http://ivyspring.com/terms for full terms and conditions. |
dc.rights.uri | https://creativecommons.org/licenses/by/4.0/ |
dc.title | MicroCT imaging reveals differential 3D micro-scale remodelling of the murine aorta in ageing and Marfan syndrome |
dc.type | info:eu-repo/semantics/article |
dc.identifier.doi | http://dx.doi.org/10.7150/thno.26598 |
dc.subject.keyword | Marfan syndrome |
dc.subject.keyword | MicroCT |
dc.subject.keyword | Aorta |
dc.subject.keyword | Ageing |
dc.subject.keyword | Elastic lamella |
dc.relation.projectID | info:eu-repo/grantAgreement/ES/1PE/BES2013-065962 |
dc.relation.projectID | info:eu-repo/grantAgreement/ES/1PE/SAF2015-64136-R |
dc.relation.projectID | info:eu-repo/grantAgreement/ES/2PE/SAF2017-83039-R |
dc.relation.projectID | info:eu-repo/grantAgreement/ES/1PE/TIN2014-52923-R |
dc.relation.projectID | info:eu-repo/grantAgreement/EC/H2020/695638 |
dc.rights.accessRights | info:eu-repo/semantics/openAccess |
dc.type.version | info:eu-repo/semantics/publishedVersion |