Show simple item record Hinzen, Wolfram Çokal, Derya Sevilla, Gabriel Jones, William Stephen Zimmerer, Vitor C. Deamer, Felicity Douglas, Maggie Spencer, Helen Turkington, Douglas Ferrier, I. Nicol Varley, Rosemary Watson, Stuart 2018-10-09T08:46:04Z 2018-10-09T08:46:04Z 2018
dc.identifier.citation Çokal D, Sevilla G, Jones WS, Zimmerer V, Deamer F, Douglas M, Spencer H, Turkington D, Ferrier N, Varley R, Watson S, Hinzen W. The language profile of formal thought disorder. NPJ Schizoph. 2018; 4. DOI: 10.1038/s41537-018-0061-9
dc.identifier.issn 2334-265X
dc.description.abstract Formal thought disorder (FTD) is clinically manifested as disorganized speech, but there have been only few investigations of its linguistic properties. We examined how disturbance of thought may relate to the referential function of language as expressed in the use of noun phrases (NPs) and the complexity of sentence structures. We used a comic strip description task to elicit language samples from 30 participants with schizophrenia (SZ), 15 with moderate or severe FTD (SZ + FTD), and 15 minimal or no FTD (SZ −FTD), as well as 15 first-degree relatives of people with SZ (FDRs) and 15 neurotypical controls (NC). We predicted that anomalies in the normal referential use of NPs, sub-divided into definite and indefinite NPs, would identify FTD; and also that FTD would also be linked to reduced linguistic complexity as specifically measured by the number of embedded clauses and of grammatical dependents. Participants with SZ + FTD produced more referential anomalies than NC and produced the fewest definite NPs, while FDRs produced the most and thus also differed from NC. When referential anomalies were classed according to the NP type in which they occurred, the SZ + FTD group produced more anomalies in definite NPs than NC. Syntactic errors did not distinguish groups, but the SZ + FTD group exhibited significantly less syntactic complexity than non-SZ groups. Exploratory regression analyses suggested that production of definite NPs distinguished the two SZ groups. These results demonstrate that FTD can be identified in specific grammatical patterns which provide new targets for detection, intervention, and neurobiological studies.
dc.description.sponsorship This research was supported by the Northumberland, Tyne and Wear NHS Mental Health Foundation Trust, including Research Capability Funding; and the Arts and Humanities Research Council (grant number AH/L004070/1 to W.H.), and the Ministerio de Economía y Competitividad, Spanish Government (grant FFI2016-77647-C2-1-P to W.H.). We would also like to thank Olivia Bailey, Laura Pearson, Jonathan Kat, Charlotte Richardson, and Sophie Clews for their transcription help. In addition, we would like to acknowledge Sarah Page and Kelsey Stoddart for their assistance in building the database.
dc.format.mimetype application/pdf
dc.language.iso eng
dc.publisher Nature Publishing Group
dc.relation.ispartof NPJ Schizoph. 2018; 4. DOI: 10.1038/s41537-018-0061-9
dc.rights © Nature Publishing Group. Creative Commons Attribution License 4.0
dc.title The language profile of formal thought disorder
dc.type info:eu-repo/semantics/article
dc.subject.keyword Schizophrenia
dc.subject.keyword Formal thought disorder
dc.subject.keyword Language and thought
dc.subject.keyword Reference
dc.subject.keyword Narrative
dc.relation.projectID info:eu-repo/grantAgreement/ES/1PE/FFI2016-77647-C2-1-P
dc.rights.accessRights info:eu-repo/semantics/openAccess
dc.type.version info:eu-repo/semantics/publishedVersion


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