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Split operator method for fluorescence diffuse optical tomography using anisotropic diffusion regularisation with prior anatomical information

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dc.contributor.author Correia, Teresa
dc.contributor.author Aguirre, Juan
dc.contributor.author Sisniega, Alejandro
dc.contributor.author Chamorro Servent, Judit
dc.contributor.author Abascal, Juan F.P.J.
dc.contributor.author Vaquero, Juan J.
dc.contributor.author Desco, Manuel
dc.contributor.author Arridge, Simon
dc.date.accessioned 2018-05-31T15:25:12Z
dc.date.available 2018-05-31T15:25:12Z
dc.date.issued 2011
dc.identifier.citation Correia, Teresa; Aguirre, Juan; Sisniega, Alejandro; Chamorro Servent, Judit; Abascal, Juan; Vaquero, Juan José; Desco, Manuel; Arridge, Simon. Split operator method for fluorescence diffuse optical tomography using anisotropic diffusion regularisation with prior anatomical information. Biomedical Optics Express 2011; 2(9): 2632-48. DOI: 10.1364/BOE.2.002632
dc.identifier.issn 2156-7085
dc.identifier.uri http://hdl.handle.net/10230/34766
dc.description.abstract Fluorescence diffuse optical tomography (fDOT) is an imaging modality that provides images of the fluorochrome distribution within the object of study. The image reconstruction problem is ill-posed and highly underdetermined and, therefore, regularisation techniques need to be used. In this paper we use a nonlinear anisotropic diffusion regularisation term that incorporates anatomical prior information. We introduce a split operator method that reduces the nonlinear inverse problem to two simpler problems, allowing fast and efficient solution of the fDOT problem. We tested our method using simulated, phantom and ex-vivo mouse data, and found that it provides reconstructions with better spatial localisation and size of fluorochrome inclusions than using the standard Tikhonov penalty term.
dc.description.sponsorship This work has also been supported in part by funding from ECs seventh framework programme FMT-XCT under Grant Agreement No. 201792 and by Comunidad de Madrid and European Regional Development Fund ARTEMIS S2009/DPI-1802.
dc.format.mimetype application/pdf
dc.language.iso eng
dc.publisher Optical Society of America (OSA)
dc.relation.ispartof Biomedical Optics Express 2011; 2(9): 2632-48.
dc.rights © 2011 Optical Society of America. Users may use, reuse, and build upon the article, or use the article for text or data mining, so long as such uses are for non-commercial purposes and appropriate attribution is maintained. All other rights are reserved.
dc.title Split operator method for fluorescence diffuse optical tomography using anisotropic diffusion regularisation with prior anatomical information
dc.type info:eu-repo/semantics/article
dc.identifier.doi http://dx.doi.org/10.1364/BOE.2.002632
dc.rights.accessRights info:eu-repo/semantics/openAccess
dc.type.version info:eu-repo/semantics/publishedVersion


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