Split operator method for fluorescence diffuse optical tomography using anisotropic diffusion regularisation with prior anatomical information

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• dc.contributor.author Correia, Teresaca
• dc.contributor.author Aguirre, Juanca
• dc.contributor.author Sisniega, Alejandroca
• dc.contributor.author Chamorro Servent, Juditca
• dc.contributor.author Abascal, Juan Felipe Pérez Justeca
• dc.contributor.author Vaquero, Juan J.ca
• dc.contributor.author Desco, Manuelca
• dc.contributor.author Arridge, Simonca
• dc.date.accessioned 2018-05-31T15:25:12Z
• dc.date.available 2018-05-31T15:25:12Z
• dc.date.issued 2011
• dc.description.abstract Fluorescence diffuse optical tomography (fDOT) is an imaging modality that provides images of the fluorochrome distribution within the object of study. The image reconstruction problem is ill-posed and highly underdetermined and, therefore, regularisation techniques need to be used. In this paper we use a nonlinear anisotropic diffusion regularisation term that incorporates anatomical prior information. We introduce a split operator method that reduces the nonlinear inverse problem to two simpler problems, allowing fast and efficient solution of the fDOT problem. We tested our method using simulated, phantom and ex-vivo mouse data, and found that it provides reconstructions with better spatial localisation and size of fluorochrome inclusions than using the standard Tikhonov penalty term.en
• dc.description.sponsorship This work has also been supported in part by funding from ECs seventh framework programme FMT-XCT under Grant Agreement No. 201792 and by Comunidad de Madrid and European Regional Development Fund ARTEMIS S2009/DPI-1802.en
• dc.format.mimetype application/pdf
• dc.identifier.citation Correia, Teresa; Aguirre, Juan; Sisniega, Alejandro; Chamorro Servent, Judit; Abascal, Juan; Vaquero, Juan José; Desco, Manuel; Arridge, Simon. Split operator method for fluorescence diffuse optical tomography using anisotropic diffusion regularisation with prior anatomical information. Biomedical Optics Express 2011; 2(9): 2632-48. DOI: 10.1364/BOE.2.002632
• dc.identifier.doi http://dx.doi.org/10.1364/BOE.2.002632
• dc.identifier.issn 2156-7085
• dc.identifier.uri http://hdl.handle.net/10230/34766
• dc.language.iso eng
• dc.publisher Optical Society of America (OSA)ca
• dc.relation.ispartof Biomedical Optics Express 2011; 2(9): 2632-48.
• dc.rights © 2011 Optical Society of America. Users may use, reuse, and build upon the article, or use the article for text or data mining, so long as such uses are for non-commercial purposes and appropriate attribution is maintained. All other rights are reserved.
• dc.rights.accessRights info:eu-repo/semantics/openAccess
• dc.title Split operator method for fluorescence diffuse optical tomography using anisotropic diffusion regularisation with prior anatomical informationca
• dc.type info:eu-repo/semantics/article
• dc.type.version info:eu-repo/semantics/publishedVersion