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Selective electroporation of liver tumor nodules by means of hypersaline infusion: a feasibility study

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dc.contributor.author Castellví Fernández, Quim
dc.contributor.author Sánchez-Velázquez, Joan
dc.contributor.author Berjano, Enrique J.
dc.contributor.author Burdío Pinilla, Fernando
dc.contributor.author Ivorra Cano, Antoni, 1974-
dc.date.accessioned 2016-04-21T12:24:52Z
dc.date.available 2016-04-21T12:24:52Z
dc.date.issued 2015
dc.identifier.citation Castellví Q, Sánchez-Velázquez P, Berjano E, Burdío F, Ivorra A. Selective electroporation of liver tumor nodules by means of hypersaline infusion: a feasibility study. In: Lackovic I, Vasic D, editors. 6th European Conference of the International Federation for Medical and Biological Engineering; 2014 Sept 7-11; Dubrovnik, Croatia. Switzerland: Springer; 2015. p.821-24. (IFMBE Proceedings; no. 45). DOI:10.1007/978-3-319-11128-5_204
dc.identifier.issn 1680-0737
dc.identifier.uri http://hdl.handle.net/10230/26156
dc.description.abstract Spread tumors in liver are not suitable to be treated with local treatments, such as conventional surgery or radiofrequency ablation, thus entailing a poor prognosis. Electroporation-based therapies imply the delivery of pulsed high electric fields and currently are performed in a local fashion using needle or plate electrodes. Here, however, it is proposed a novel electroporation paradigm in which field delivery is not local. All the tumor nodules will be selectively treated using large plate electrodes at both sides of the liver. By infusing an hypersaline solution of high electrical conductivity through the portal vein, the electrical conductivity of healthy tissues and tumor nodules will be made significantly different so that the electric field will be focused on the undesirable tissues. Numerical simulations were used to evaluate the feasibility of the proposed technique. In addition, an in vivo procedure was carried out to assess whether it is possible and practical to significantly modify the conductivity of the liver tissue by hypersaline infusion. Both the numerical simulations and the in vivo procedure provided encouraging results.
dc.description.sponsorship This work received financial support from the Spanish “Plan Nacional de I+D+I del Ministerio de Ciencia e Innovación” Grants No. TEC2011-27133-C02-01,02 and TEC2010-17285 and from the European Commission through the Marie Curie grant TAMIVIVE (256376).
dc.format.mimetype application/pdf
dc.language.iso eng
dc.publisher Springer
dc.relation.ispartof Lackovic I, Vasic D, editors. 6th European Conference of the International Federation for Medical and Biological Engineering; 2014 Sept 7-11; Dubrovnik, Croatia. Switzerland: Springer; 2015. p.821-24. (IFMBE Proceedings; no. 45).
dc.rights © Springer The final publication is available at Springer via/nhttp://dx.doi.org/10.1007/978-3-319-11128-5_204
dc.title Selective electroporation of liver tumor nodules by means of hypersaline infusion: a feasibility study
dc.type info:eu-repo/semantics/conferenceObject
dc.identifier.doi http://dx.doi.org/10.1007/978-3-319-11128-5_204
dc.subject.keyword Electroporation
dc.subject.keyword Liver
dc.subject.keyword Spread tumors
dc.subject.keyword Disseminated nodules
dc.subject.keyword Hypersaline
dc.relation.projectID info:eu-repo/grantAgreement/EC/FP7/256376
dc.relation.projectID info:eu-repo/grantAgreement/ES/3PN/TEC2010-17285
dc.rights.accessRights info:eu-repo/semantics/openAccess
dc.type.version info:eu-repo/semantics/acceptedVersion


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