Phase-locking of epileptic spikes to ongoing delta oscillations in non-convulsive status epilepticus

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• dc.contributor.author Hindriks, Rikkert
• dc.contributor.author Meijer, Hil G. E.
• dc.contributor.author van Gils, Stephan A.
• dc.contributor.author van Putten, Michel J. A. M.
• dc.date.accessioned 2024-01-23T07:19:35Z
• dc.date.available 2024-01-23T07:19:35Z
• dc.date.issued 2013
• dc.description.abstract The EEG of patients in non-convulsive status epilepticus (NCSE) often displays delta oscillations or generalized spike-wave discharges. In some patients, these delta oscillations coexist with intermittent epileptic spikes. In this study we verify the prediction of a computational model of the thalamo-cortical system that these spikes are phase-locked to the delta oscillations. We subsequently describe the physiological mechanism underlying this observation as suggested by the model. It is suggested that the spikes reflect inhibitory stochastic fluctuations in the input to thalamo-cortical relay neurons and phase-locking is a consequence of differential excitability of relay neurons over the delta cycle. Further analysis shows that the observed phase-locking can be regarded as a stochastic precursor of generalized spike-wave discharges. This study thus provides an explanation of intermittent spikes during delta oscillations in NCSE and might be generalized to other encephathologies in which delta activity can be observed.
• dc.format.mimetype application/pdf
• dc.identifier.citation Hindriks R, Meijer HGE, van Gils SA, van Putten MJAM. Phase-locking of epileptic spikes to ongoing delta oscillations in non-convulsive status epilepticus. Front Syst Neurosci. 2013 Dec 16;7:111. DOI: 10.3389/fnsys.2013.00111
• dc.identifier.doi http://dx.doi.org/10.3389/fnsys.2013.00111
• dc.identifier.issn 1662-5137
• dc.identifier.uri http://hdl.handle.net/10230/58793
• dc.language.iso eng
• dc.publisher Frontiers
• dc.relation.ispartof Frontiers in Systems Neuroscience. 2013 Dec 16;7:111
• dc.rights © 2013 Hindriks, Meijer, van Gils and van Putten. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
• dc.rights.accessRights info:eu-repo/semantics/openAccess
• dc.rights.uri http://creativecommons.org/licenses/by/3.0/
• dc.subject.keyword Absence status
• dc.subject.keyword Delta oscillation
• dc.subject.keyword Absence seizure
• dc.subject.keyword Spike-wave discharge
• dc.subject.keyword Phase-locking
• dc.subject.keyword Thalamo-cortical system
• dc.title Phase-locking of epileptic spikes to ongoing delta oscillations in non-convulsive status epilepticus
• dc.type info:eu-repo/semantics/article
• dc.type.version info:eu-repo/semantics/publishedVersion