Structural connectivity in schizophrenia and its impact on the dynamics of spontaneous functional networks

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  • dc.contributor.author Cabral, Joanaca
  • dc.contributor.author Fernandes, Henrique M.ca
  • dc.contributor.author Van Hartevelt, Tim J.ca
  • dc.contributor.author James, Anthony C.ca
  • dc.contributor.author Kringelbach, Morten L.ca
  • dc.contributor.author Deco, Gustavoca
  • dc.date.accessioned 2015-01-27T08:32:00Z
  • dc.date.available 2015-01-27T08:32:00Z
  • dc.date.issued 2013ca
  • dc.description.abstract The neuropathology of schizophrenia remains unclear. Some insight has come from modern/nneuroimaging techniques, which offer an unparalleled opportunity to explore/nin vivo/nthe structure/nand function of the brain. Using functional magnetic resonance imaging, it has been found that the/nlarge-scale resting-state functional connectivity (rsFC) in schizophrenia — measured as the/ntemporal correlations of the blood-oxygen-level-dependent (BOLD) signal — exhibit altered/nnetwork topology, with lower small-world index. The origin of these rsFC alterations and link with/nthe underlying structural connectivity remain unclear. In this work, we used a computational model/nof spontaneous large-scale brain activity to explore the role of the structural connectivity in the/nlarge-scale dynamics of the brain in health and schizophrenia. The structural connectomes from 15/nadolescent patients with early-onset schizophrenia and 15 age- and gender-matched controls were/nbuilt from diffusion tensor imaging data to detect the white matter tracts between 90 brain areas./nBrain areas, simulated using a reduced dynamic mean-field model, receive excitatory input from/nother areas in proportion to the number of fibre tracts between them. The simulated mean field/nactivity was transformed into BOLD signal, and the properties of the simulated functional networks/nwere analyzed. Our results suggest that the functional alterations observed in schizophrenia are not/ndirectly linked to alterations in the structural topology. Instead, subtly randomized and less/nsmall-world functional networks appear when the brain operates with lower global coupling, which/nshifts the dynamics from the optimal healthy regime.en
  • dc.description.sponsorship The research reported herein was supported by the ERC/nAdvanced Grant DYSTRUCTURE (No. 295129), by the/nFET Flagship Human Brain Project, by the Spanish Research/nProject SAF2010-16085, by the CONSOLIDER-INGENIO/n2010 Programme CSD2007-00012, by the Brain Network/nRecovery Group through the James S. McDonnell/nFoundation, by the FP7-ICT BrainScales, and by the/nTrygFonden Charitable Foundation. Funding for the scan-/nning was supported by the MRC (G0500092).en
  • dc.format.extent 10 p.
  • dc.format.mimetype application/pdfca
  • dc.identifier.citation Cabral J, Fernandes HM, Van Hartevelt TJ, James AC, Kringelbach, ML, Deco G. Structural connectivity in schizophrenia and its impact on the dynamics of spontaneous functional networks. Chaos. 2013 Dec 23;23(4):046111. DOI 10.1063/1.4851117ca
  • dc.identifier.doi http://dx.doi.org/10.1063/1.4851117
  • dc.identifier.issn 1054-1500ca
  • dc.identifier.uri http://hdl.handle.net/10230/23076
  • dc.language.iso engca
  • dc.publisher American Institute of Physics (AIP)ca
  • dc.relation.ispartof Chaos. 2013 Dec 23;23(4):046111
  • dc.relation.projectID info:eu-repo/grantAgreement/EC/FP7/295129ca
  • dc.relation.projectID info:eu-repo/grantAgreement/EC/FP7/269921
  • dc.relation.projectID info:eu-repo/grantAgreement/ES/3PN/SAF2010-16085
  • dc.relation.projectID info:eu-repo/grantAgreement/ES/2PN/CSD2007-00012
  • dc.rights © American Institute of Physics. This article appeared in Cabral J et al., Chaos, Vol. 23(4), 2013 and may be found at http://dx.doi.org/10.1063/1.4851117ca
  • dc.rights.accessRights info:eu-repo/semantics/openAccessca
  • dc.title Structural connectivity in schizophrenia and its impact on the dynamics of spontaneous functional networksca
  • dc.type info:eu-repo/semantics/articleca
  • dc.type.version info:eu-repo/semantics/publishedVersionca

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