Assessment of wall elasticity variations on intraluminal haemodynamics in descending aortic dissections using a lumped-parameter model
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- dc.contributor.author Rudenick, Paula A.ca
- dc.contributor.author Bijnens, Bartca
- dc.contributor.author Segers, Patrick F.ca
- dc.contributor.author García-Dorado, Davidca
- dc.contributor.author Evangelista, Arturoca
- dc.date.accessioned 2016-05-23T12:49:43Z
- dc.date.available 2016-05-23T12:49:43Z
- dc.date.issued 2015
- dc.description.abstract Descending aortic dissection (DAD) is associated with high morbidity and mortality rates. Aortic wall stiffness is a variable often altered in DAD patients and potentially involved in long-term outcome. However, its relevance is still mostly unknown. To gain more detailed knowledge of how wall elasticity (compliance) might influence intraluminal haemodynamics in DAD, a lumped-parameter model was developed based on experimental data from a pulsatile hydraulic circuit and validated for 8 clinical scenarios. Next, the variations of intraluminal pressures and flows were assessed as a function of wall elasticity. In comparison with the most rigid-wall case, an increase in elasticity to physiological values was associated with a decrease in systolic and increase in diastolic pressures of up to 33% and 63% respectively, with a subsequent decrease in the pressure wave amplitude of up to 86%. Moreover, it was related to an increase in multidirectional intraluminal flows and transition of behaviour as 2 parallel vessels towards a vessel with a side-chamber. The model supports the extremely important role of wall elasticity as determinant of intraluminal pressures and flow patterns for DAD, and thus, the relevance of considering it during clinical assessment and computational modelling of the disease.en
- dc.description.sponsorship This study was partially supported by the Subprograma de Proyectos de Investigación en Salud (FIS), Instituto de Salud Carlos III, Spain (ref. PI108/0608, PI11/01709); the Programa de ayudas destinadas a universidades, centros de investigación y fundaciones hospitalarias para la contratación de personal investigador novel (FI-DGR 2011), Spain; and the EU FP7 for research, technological development and demonstration under grant agreement VP2HF (no 611823).en
- dc.format.mimetype application/pdfca
- dc.identifier.citation Rudenick PA, Bijnens BH, Segers P, Garcia-Dorado D, Evangelista A. Assessment of wall elasticity variations on intraluminal haemodynamics in descending aortic dissections using a lumped-parameter model. PLoS ONE. 2015;10(4):e0124011. doi: 10.1371/journal.pone.0124011en
- dc.identifier.doi http://dx.doi.org/10.1371/journal.pone.0124011
- dc.identifier.issn 1932-6203
- dc.identifier.uri http://hdl.handle.net/10230/26325
- dc.language.iso engen
- dc.publisher Public Library of Science (PLoS)en
- dc.relation.ispartof PLoS ONE. 2015;10(4):e0124011en
- dc.relation.projectID info:eu-repo/grantAgreement/EC/FP7/611823
- dc.rights © 2015 Rudenick et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.en
- dc.rights.accessRights info:eu-repo/semantics/openAccess
- dc.rights.uri http://creativecommons.org/licenses/by/4.0/
- dc.subject.keyword Systolic pressureen
- dc.subject.keyword Fluid flowen
- dc.subject.keyword Stiffnessen
- dc.subject.keyword Mathematical modelsen
- dc.subject.keyword Catheterizationen
- dc.subject.keyword Flow rateen
- dc.subject.keyword Aortaen
- dc.subject.keyword Simulation and modelingen
- dc.title Assessment of wall elasticity variations on intraluminal haemodynamics in descending aortic dissections using a lumped-parameter modelen
- dc.type info:eu-repo/semantics/article
- dc.type.version info:eu-repo/semantics/publishedVersion