Consensus paper: towards a systems-level view of cerebellar function: the interplay between cerebellum, basal ganglia, and cortex

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• dc.contributor.author Caligiore, Daniele
• dc.contributor.author Pezzulo, Giovanni
• dc.contributor.author Baldassarre, Gianluca
• dc.contributor.author Bostan, Andreea C.
• dc.contributor.author Strick, Peter L.
• dc.contributor.author Doya, Kenji
• dc.contributor.author Helmich, Rick C.
• dc.contributor.author Dirkx, Michiel
• dc.contributor.author Houk, James
• dc.contributor.author Jörntell, Henrik
• dc.contributor.author Lago-Rodriguez, Angel
• dc.contributor.author Galea, Joseph M.
• dc.contributor.author Miall, R. Chris
• dc.contributor.author Popa, Traian
• dc.contributor.author Kishore, Asha
• dc.contributor.author Verschure, Paul F. M. J.
• dc.contributor.author Zucca, Riccardo
• dc.contributor.author Herreros, Ivan
• dc.date.accessioned 2023-06-06T06:26:42Z
• dc.date.available 2023-06-06T06:26:42Z
• dc.date.issued 2017
• dc.description.abstract Despite increasing evidence suggesting the cerebellum works in concert with the cortex and basal ganglia, the nature of the reciprocal interactions between these three brain regions remains unclear. This consensus paper gathers diverse recent views on a variety of important roles played by the cerebellum within the cerebello-basal ganglia-thalamo-cortical system across a range of motor and cognitive functions. The paper includes theoretical and empirical contributions, which cover the following topics: recent evidence supporting the dynamical interplay between cerebellum, basal ganglia, and cortical areas in humans and other animals; theoretical neuroscience perspectives and empirical evidence on the reciprocal influences between cerebellum, basal ganglia, and cortex in learning and control processes; and data suggesting possible roles of the cerebellum in basal ganglia movement disorders. Although starting from different backgrounds and dealing with different topics, all the contributors agree that viewing the cerebellum, basal ganglia, and cortex as an integrated system enables us to understand the function of these areas in radically different ways. In addition, there is unanimous consensus between the authors that future experimental and computational work is needed to understand the function of cerebellar-basal ganglia circuitry in both motor and non-motor functions. The paper reports the most advanced perspectives on the role of the cerebellum within the cerebello-basal ganglia-thalamo-cortical system and illustrates other elements of consensus as well as disagreements and open questions in the field.
• dc.description.sponsorship The present research was supported by the European Commission 7th Framework Programme (FP7/2007-2013), “Challenge 2—Cognitive Systems, Interaction, Robotics,” grant agreement No. ICT IP-231722, project “IM-CLeVeR—Intrinsically Motivated Cumulative Learning Versatile Robots” to D. Caligiore; by the Human Frontier Science Program (HFSP), award number RGY0088/2014 to G. Pezzulo; in parts by funds from the Office of Research and Development, Medical Research Service, Department of Veterans Affairs and National Institutes of Health Grants R01 NS24328, R01 MH56661, P40 OD010996, and P30 NS076405 to P. L. Strick; by the European Research Council project MotMotLearn (637488) to J. Galea; by the MRC (grant R/J012610/1) to R.C. Miall and Wellcome Trust, grant WT087554 to R.C. Miall and A. Lago-Rodriguez; by the European Research Council under the European Union’s Seventh Framework Programme (FP7/2007-2013)/ERC grant agreement no. 341196 to P. F. M. J. Verschure; and by the European Commission’s Horizon 2020 socSMC (under agreement number socSMC-641321H2020-FETPROACT-2014) to I. Herreros. We thank the two anonymous reviewers and Professor Michael A. Arbib who have contributed to enhance the quality of this consensus paper with precious comments.
• dc.format.mimetype application/pdf
• dc.identifier.citation Caligiore D, Pezzulo G, Baldassarre G, Bostan AC, Strick PL, Doya K, et al. Consensus paper: towards a systems-level view of cerebellar function: the interplay between cerebellum, basal ganglia, and cortex. Cerebellum. 2017 Feb 1;16(1):203-29. DOI: 10.1007/s12311-016-0763-3
• dc.identifier.doi http://dx.doi.org/10.1007/s12311-016-0763-3
• dc.identifier.issn 1473-4230
• dc.identifier.uri http://hdl.handle.net/10230/57074
• dc.language.iso eng
• dc.publisher Springer
• dc.relation.ispartof Cerebellum. 2017 Feb 1;16(1):203-29
• dc.relation.projectID info:eu-repo/grantAgreement/EC/FP7/231722
• dc.relation.projectID info:eu-repo/grantAgreement/EC/FP7/637488
• dc.relation.projectID info:eu-repo/grantAgreement/EC/FP7/341196
• dc.relation.projectID info:eu-repo/grantAgreement/EC/H2020/641321
• dc.rights This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
• dc.rights.accessRights info:eu-repo/semantics/openAccess
• dc.rights.uri http://creativecommons.org/licenses/by/4.0/
• dc.subject.keyword Basal ganglia cerebellum anatomical link
• dc.subject.keyword Nucleo-olivary inhibition
• dc.subject.keyword Movement disorders
• dc.subject.keyword Parkinson’s disease tremor
• dc.subject.keyword Cerebellar motor and cognitive function
• dc.subject.keyword Non-invasive brain stimulation
• dc.title Consensus paper: towards a systems-level view of cerebellar function: the interplay between cerebellum, basal ganglia, and cortex
• dc.type info:eu-repo/semantics/article
• dc.type.version info:eu-repo/semantics/publishedVersion