Spontaneous cortical activity is transiently poised close to criticality

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• dc.contributor.author Hahn, Gerald
• dc.contributor.author Ponce-Alvarez, Adrián
• dc.contributor.author Monier, Cyril
• dc.contributor.author Benvenuti, Giacomo
• dc.contributor.author Kumar, Arvind
• dc.contributor.author Chavane, Frédéric
• dc.contributor.author Deco, Gustavo
• dc.contributor.author Frégnac, Yves
• dc.date.accessioned 2019-04-08T08:45:46Z
• dc.date.available 2019-04-08T08:45:46Z
• dc.date.issued 2017
• dc.description.abstract Brain activity displays a large repertoire of dynamics across the sleep-wake cycle and even during anesthesia. It was suggested that criticality could serve as a unifying principle underlying the diversity of dynamics. This view has been supported by the observation of spontaneous bursts of cortical activity with scale-invariant sizes and durations, known as neuronal avalanches, in recordings of mesoscopic cortical signals. However, the existence of neuronal avalanches in spiking activity has been equivocal with studies reporting both its presence and absence. Here, we show that signs of criticality in spiking activity can change between synchronized and desynchronized cortical states. We analyzed the spontaneous activity in the primary visual cortex of the anesthetized cat and the awake monkey, and found that neuronal avalanches and thermodynamic indicators of criticality strongly depend on collective synchrony among neurons, LFP fluctuations, and behavioral state. We found that synchronized states are associated to criticality, large dynamical repertoire and prolonged epochs of eye closure, while desynchronized states are associated to sub-criticality, reduced dynamical repertoire, and eyes open conditions. Our results show that criticality in cortical dynamics is not stationary, but fluctuates during anesthesia and between different vigilance states.
• dc.description.sponsorship GH, CM and YF were supported by the CNRS, the Agence Nationale de la Recherche (ANR: V1-Complex) https://www.cnrs.fr. GH and GB were financed by the initial training network program FACETS-ITN (PITN-GA-2009- 237955) http://facets.kip.uni-heidelberg.de/ITN/. APA was supported by SEMAINE ERA-Net NEURON Project and by a Juan de la Cierva fellowship (IJCI-2014-21066) from the Spanish Ministry of Economy and Competitiveness. CM, GD and YF received funding from the EC grants BrainScales (FP7-2010- IST-FETPI 269921) and the flagship Human Brain Project (n.604102) https://www.humanbrainproject.eu/. The Utah array recordings were made possible through a loan by S.GruÈn (Research Center JuÈlich, INM6, Germany) and were part of a collaborative work with S. GruÈn and A. Riehle (INT, Marseille). AK received funding from the German Federal Ministry of Education and Research (BMBF 01GQ0420 to BCCN Freiburg and 01GQ0830 to BFNT Freiburg/TuÈbingen) https://www.bmbf.de/en/. GD is supported by the ERC Advanced Grant: DYSTRUCTURE (n. 295129), by the Spanish Research Project PSI2016-75688-P and by the the European Union's Horizon 2020 research and innovation programme under grant agreement n. 720270 (HBP SGA1). GD obtained support from the ERC Advanced Grant DYSTRUCTURE (n. 295129) gustavodecolab.com/dystructure/ and the Spanish Research Project PSI2013-42091- P. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.
• dc.format.mimetype application/pdf
• dc.identifier.citation Hahn G, Ponce-Alvarez A, Monier C, Benvenuti G, Kumar A, Chavane F, Deco G, Frégnac Y. Spontaneous cortical activity is transiently poised close to criticality. PLoS One. 2017 May 24;13(5):e1005543. DOI: 10.1371/journal.pcbi.1005543
• dc.identifier.doi http://dx.doi.org/10.1371/journal.pcbi.1005543
• dc.identifier.issn 1932-6203
• dc.identifier.uri http://hdl.handle.net/10230/37057
• dc.language.iso eng
• dc.publisher Public Library of Science (PLoS)
• dc.relation.ispartof PLoS One. 2017 May 24;13(5):e1005543
• dc.relation.isreferencedby https://figshare.com/articles/Spontaneous_cortical_activity_is_transiently_poised_close_to_criticality/5036240
• dc.relation.projectID info:eu-repo/grantAgreement/ES/1PE/IJCI2014-21066
• dc.relation.projectID info:eu-repo/grantAgreement/EC/FP7/237955
• dc.relation.projectID info:eu-repo/grantAgreement/EC/FP7/269921
• dc.relation.projectID info:eu-repo/grantAgreement/EC/FP7/604102
• dc.relation.projectID info:eu-repo/grantAgreement/ES/1PE/PSI2016-75688-P
• dc.relation.projectID info:eu-repo/grantAgreement/EC/FP7/295129
• dc.relation.projectID info:eu-repo/grantAgreement/EC/H2020/720270
• dc.relation.projectID info:eu-repo/grantAgreement/ES/1PE/PSI2013-42091-P
• dc.rights © 2017 Hahn et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
• dc.rights.accessRights info:eu-repo/semantics/openAccess
• dc.rights.uri https://creativecommons.org/licenses/by/4.0/
• dc.subject.keyword Cats
• dc.subject.keyword Monkeys
• dc.subject.keyword Neurons
• dc.subject.keyword Action potentials
• dc.subject.keyword Entropy
• dc.subject.keyword Eyes
• dc.subject.keyword Anesthesia
• dc.subject.keyword Neural networks
• dc.title Spontaneous cortical activity is transiently poised close to criticality
• dc.type info:eu-repo/semantics/article
• dc.type.version info:eu-repo/semantics/publishedVersion