Spatiotemporal whole-brain activity and functional connectivity of melodies recognition

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• dc.contributor.author Bonetti, Leonardo
• dc.contributor.author Brattico, Elvira
• dc.contributor.author Carlomagno, Francesco
• dc.contributor.author Cabral, Joana
• dc.contributor.author Stevner, Angus
• dc.contributor.author Deco, Gustavo
• dc.contributor.author Whybrow, Peter C.
• dc.contributor.author Pearce, Marcus
• dc.contributor.author Pantazis, Dimitrios
• dc.contributor.author Vuust, Peter
• dc.contributor.author Kringelbach, Morten L.
• dc.date.accessioned 2025-05-19T07:54:26Z
• dc.date.available 2025-05-19T07:54:26Z
• dc.date.issued 2024
• dc.description.abstract Music is a non-verbal human language, built on logical, hierarchical structures, that offers excellent opportunities to explore how the brain processes complex spatiotemporal auditory sequences. Using the high temporal resolution of magnetoencephalography, we investigated the unfolding brain dynamics of 70 participants during the recognition of previously memorized musical sequences compared to novel sequences matched in terms of entropy and information content. Measures of both whole-brain activity and functional connectivity revealed a widespread brain network underlying the recognition of the memorized auditory sequences, which comprised primary auditory cortex, superior temporal gyrus, insula, frontal operculum, cingulate gyrus, orbitofrontal cortex, basal ganglia, thalamus, and hippocampus. Furthermore, while the auditory cortex responded mainly to the first tones of the sequences, the activity of higher-order brain areas such as the cingulate gyrus, frontal operculum, hippocampus, and orbitofrontal cortex largely increased over time during the recognition of the memorized versus novel musical sequences. In conclusion, using a wide range of analytical techniques spanning from decoding to functional connectivity and building on previous works, our study provided new insights into the spatiotemporal whole-brain mechanisms for conscious recognition of auditory sequences.
• dc.description.sponsorship The Center for Music in the Brain (MIB) is funded by the Danish National Research Foundation (project number DNRF117). L.B. is supported by Lundbeck Foundation (Talent Prize 2022), Carlsberg Foundation (CF20-0239), Center for Music in the Brain, Linacre College of the University of Oxford, and Society for Education and Music Psychology (SEMPRE’s 50th Anniversary Awards Scheme). M.L.K. is supported by Center for Music in the Brain, funded by the Danish National Research Foundation (DNRF117), and Centre for Eudaimonia and Human Flourishing funded by the Pettit and Carlsberg Foundations. G.D. is supported by the Spanish Research Project PSI2016-75688-P (AEI/FEDER, EU), by the European Union’s Horizon 2020 Research and Innovation Programme under grant agreements n. 720270 (HBP SGA1) and n. 785907 (HBP SGA2), and by the Catalan AGAUR Programme 2017 SGR 1545. J. C. is supported by La Caixa Foundation, Spain (LCF/BQ/PR22/11920014) and the Foundation for Science and Technology, Portugal (UIDB/50026/2020, UIDP/50026/2020). Additionally, we thank the Italian section of Mensa: The International High IQ Society for the economic support provided to the author Francesco Carlomagno and the University of Bologna for the economic support provided to the students Giulia Donati, Riccardo Proietti, and Giulio Carraturo.
• dc.format.mimetype application/pdf
• dc.identifier.citation Bonetti L, Brattico E, Carlomagno F, Cabral J, Stevner A, Deco G, et al. Spatiotemporal whole-brain activity and functional connectivity of melodies recognition. Cereb Cortex. 2024 Aug;34(8):bhae320. DOI: 10.1093/cercor/bhae320
• dc.identifier.doi http://dx.doi.org/10.1093/cercor/bhae320
• dc.identifier.issn 1047-3211
• dc.identifier.uri http://hdl.handle.net/10230/70433
• dc.language.iso eng
• dc.publisher Oxford University Press
• dc.relation.ispartof Cerebral Cortex. 2024 Aug;34(8):bhae320
• dc.relation.projectID info:eu-repo/grantAgreement/EC/H2020/720270
• dc.relation.projectID info:eu-repo/grantAgreement/EC/H2020/785907
• dc.relation.projectID info:eu-repo/grantAgreement/ES/1PE/PSI2016-75688-P
• dc.rights © The Author(s) 2024. Published by Oxford University Press. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.
• dc.rights.accessRights info:eu-repo/semantics/openAccess
• dc.rights.uri http://creativecommons.org/licenses/by/4.0/
• dc.subject.keyword Memory
• dc.subject.keyword Sequence recognition
• dc.subject.keyword Brain spatiotemporal dynamics
• dc.subject.keyword Functional connectivity
• dc.subject.keyword Magnetoencephalography (MEG)
• dc.title Spatiotemporal whole-brain activity and functional connectivity of melodies recognition
• dc.type info:eu-repo/semantics/article
• dc.type.version info:eu-repo/semantics/publishedVersion