Irreversible electroporation shows efficacy against pancreatic carcinoma without systemic toxicity in mouse models

José Segarra-Martínez, Anabel; Sobrevals, Luciano; Ivorra Cano, Antoni, 1974-; Fillat i Fonts, Cristina

doi:http://dx.doi.org/10.1016/j.canlet.2011.11.004

Irreversible electroporation shows efficacy against pancreatic carcinoma without systemic toxicity in mouse models

Citation

José A, Sobrevals L, Ivorra A, Fillat C. Irreversible electroporation shows efficacy against pancreatic carcinoma without systemic toxicity in mouse models. Cancer Lett. 2012;317(1):16-23. DOI:10.1016/j.canlet.2011.11.004

Abstract

Pancreatic Ductal Adenocarcinoma (PDAC) therapies show limited success./nIrreversible electroporation (IRE) is an innovative loco-regional therapy in which highvoltage pulses are applied to induce plasma membrane defects leading to cellular death. In the present study we evaluated the feasibility of IRE against PDAC. IRE/ntreatment exhibited significant antitumor effects and prolonged survival in mice with orthotopic xenografts. Extensive tumor necrosis, reduced tumor cell proliferation and disruption of microvessels were observed at different days post-IRE. Animals had transient increases in transaminases, amylase and lipase enzymes that normalized at/n24h post-IRE. These results suggest that IRE could be an effective treatment for locally advanced pancreatic tumors.