The bivalent genome: characterization, structure, and regulation

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  • dc.contributor.author Blanco, Enrique
  • dc.contributor.author González Ramírez, Mar, 1991-
  • dc.contributor.author Alcaine Colet, Anna, 1992-
  • dc.contributor.author Aranda Aragón, Sergio
  • dc.contributor.author Di Croce, Luciano
  • dc.date.accessioned 2020-04-03T07:28:37Z
  • dc.date.issued 2020
  • dc.description.abstract An intricate molecular machinery is at the core of gene expression regulation in every cell. During the initial stages of organismal development, the coordinated activation of diverse transcriptional programs is crucial and must be carefully executed to shape every organ and tissue. Bivalent promoters and poised enhancers are regulatory regions decorated with histone marks that are associated with both positive and negative transcriptional outcomes. These apparently contradictory signals are important for setting bivalent genes in a poised state, which is subsequently resolved during differentiation into either active or repressive states. We discuss the origins of bivalent promoters and the mechanisms implicated in their acquisition and maintenance. We further review how the presence of bivalent marks influences genome architecture. Finally, we highlight the potential link between bivalency and cancer which could drive biomedical research in disease etiology and treatment.
  • dc.description.sponsorship Work in the laboratory of L.D.C. is supported by grants from the Spanish of Economy, Industry, and Competitiveness (MEIC; BFU2016-75008-P), the Fundacion Vencer El Cancer (VEC), the European Regional Development Fund (FEDER), and the Catalan Agency for Management of University and Research Grants (AGAUR). We also acknowledge support from the MEIC (through the Instituto de Salud Carlos III and an EMBL partnership), the Centro de Excelencia Severo Ochoa, and the CERCA Programme/Generalitat de Catalunya.
  • dc.format.mimetype application/pdf
  • dc.identifier.citation Blanco E, González-Ramírez M, Alcaine-Colet A, Aranda S, Di Croce L. The bivalent genome: characterization, structure, and regulation. Trends Genet. 2020; 36(2):118-31. DOI: 10.1016/j.tig.2019.11.004
  • dc.identifier.doi http://dx.doi.org/10.1016/j.tig.2019.11.004
  • dc.identifier.issn 0168-9525
  • dc.identifier.uri http://hdl.handle.net/10230/44154
  • dc.language.iso eng
  • dc.publisher Elsevier
  • dc.relation.ispartof Trends Genet. 2020; 36(2):118-31
  • dc.relation.projectID info:eu-repo/grantAgreement/ES/1PE/BFU2016-75008-P
  • dc.rights © Elsevier http://dx.doi.org/10.1016/j.tig.2019.11.004
  • dc.rights.accessRights info:eu-repo/semantics/openAccess
  • dc.subject.keyword Bivalency
  • dc.subject.keyword Cancer
  • dc.subject.keyword Cell differentiation
  • dc.subject.keyword Epigenetics
  • dc.subject.keyword Histone marks
  • dc.subject.keyword Stem cells
  • dc.title The bivalent genome: characterization, structure, and regulation
  • dc.type info:eu-repo/semantics/article
  • dc.type.version info:eu-repo/semantics/acceptedVersion

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Articles (Center for Genomic Regulation (CRG))
Articles (Departament de Medicina i Ciències de la Vida)