The bivalent genome: characterization, structure, and regulation

Blanco, Enrique; González Ramírez, Mar, 1991-; Alcaine Colet, Anna, 1992-; Aranda Aragón, Sergio; Di Croce, Luciano

doi:http://dx.doi.org/10.1016/j.tig.2019.11.004

The bivalent genome: characterization, structure, and regulation

Citation

Blanco E, González-Ramírez M, Alcaine-Colet A, Aranda S, Di Croce L. The bivalent genome: characterization, structure, and regulation. Trends Genet. 2020; 36(2):118-31. DOI: 10.1016/j.tig.2019.11.004

Abstract

An intricate molecular machinery is at the core of gene expression regulation in every cell. During the initial stages of organismal development, the coordinated activation of diverse transcriptional programs is crucial and must be carefully executed to shape every organ and tissue. Bivalent promoters and poised enhancers are regulatory regions decorated with histone marks that are associated with both positive and negative transcriptional outcomes. These apparently contradictory signals are important for setting bivalent genes in a poised state, which is subsequently resolved during differentiation into either active or repressive states. We discuss the origins of bivalent promoters and the mechanisms implicated in their acquisition and maintenance. We further review how the presence of bivalent marks influences genome architecture. Finally, we highlight the potential link between bivalency and cancer which could drive biomedical research in disease etiology and treatment.