Absence of parallel fibre to purkinje cell LTD during eyeblink conditioning

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• dc.contributor.author Johansson, Fredrik
• dc.contributor.author Jirenhed, Dan Anders
• dc.contributor.author Rasmussen, Anders
• dc.contributor.author Zucca, Riccardo
• dc.contributor.author Hesslow, Germund
• dc.date.accessioned 2020-02-27T15:16:30Z
• dc.date.available 2020-02-27T15:16:30Z
• dc.date.issued 2018
• dc.description.abstract Long-term depression (LTD) of parallel fibre/Purkinje cell synapses has been the favoured explanation for cerebellar motor learning such as classical eyeblink conditioning. Previous evidence against this interpretation has been contested. Here we wanted to test whether a classical conditioning protocol causes LTD. We applied a conditioning protocol, using a train of electrical pulses to the parallel fibres as the conditional stimulus. In order to rule out indirect effects caused by antidromic granule cell activation or output from Purkinje cells that might produce changes in Purkinje cell responsiveness, we focused the analysis on the first pulse in the conditional stimulus, that is, before any indirect effects would have time to occur. Purkinje cells learned to respond with a firing pause to the conditional stimulus. Yet, there was no depression of parallel fibre excitation after training.
• dc.description.sponsorship This work was supported by grants from the Swedish Research Council to The Linnaeus Centre for Cognition, Communication and Learning (349-2007-8695) and to G. Hesslow (09899) and from the Torsten Söderberg foundation.
• dc.format.mimetype application/pdf
• dc.identifier.citation Johansson F, Jirenhed D, Rasmussen A, Zucca R, Hesslow G. Absence of parallel fibre to purkinje cell LTD during eyeblink conditioning. Sci Rep. 2018 Oct 3;8(1):14777. DOI: 10.1038/s41598-018-32791-7
• dc.identifier.doi http://dx.doi.org/10.1038/s41598-018-32791-7
• dc.identifier.issn 2045-2322
• dc.identifier.uri http://hdl.handle.net/10230/43732
• dc.language.iso eng
• dc.publisher Nature Research
• dc.relation.ispartof Scientific Reports. 2018 Oct 3;8(1):14777
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• dc.rights.accessRights info:eu-repo/semantics/openAccess
• dc.rights.uri http://creativecommons.org/licenses/by/4.0/
• dc.subject.keyword Cerebellum
• dc.subject.keyword Classical conditioning
• dc.title Absence of parallel fibre to purkinje cell LTD during eyeblink conditioning
• dc.type info:eu-repo/semantics/article
• dc.type.version info:eu-repo/semantics/publishedVersion