The Phase of Theta oscillations modulates successful memory formation at encoding

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  • dc.contributor.author Cruzat Grand, Josefina, 1983-
  • dc.contributor.author Torralba, Mireia
  • dc.contributor.author Ruzzoli, Manuela
  • dc.contributor.author Fernández, Alba
  • dc.contributor.author Deco, Gustavo
  • dc.contributor.author Soto-Faraco, Salvador, 1970-
  • dc.date.accessioned 2021-05-10T07:56:02Z
  • dc.date.issued 2021
  • dc.description.abstract Several studies have shown that attention and perception can depend upon the phase of ongoing neural oscillations at stimulus onset. Here, we extend this idea to the memory domain. We tested the hypothesis that ongoing fluctuations in neural activity impact memory encoding in two experiments using a picture paired-associates task in order to gauge episodic memory performance. Experiment 1 was behavioural only and capitalized on the principle of phase resetting. We tested if subsequent memory performance fluctuates rhythmically, time-locked to a resetting cue presented before the to-be-remembered pairs at different time intervals. We found an indication that behavioural performance was periodically and selectively modulated at Theta frequency (~4 Hz). In Experiment 2, we focused on pre-stimulus ongoing activity using scalp EEG while participants performed a paired-associates task. The pre-registered analysis, using large electrode clusters and generic Theta and Alpha spectral ranges, returned null results of the pre-stimulus phase-behaviour correlation. However, as expected from prior literature, we found that variations in stimulus-related Theta-power predicted subsequent memory performance. Therefore, we used this post-stimulus effect in Theta power to guide a post-hoc pre-stimulus phase analysis in terms of scalp and frequency of interest. This analysis returned a correlation between the pre-stimulus Theta phase and subsequent memory. Altogether, these results suggest that pre-stimulus Theta activity at encoding may impact later memory performance.
  • dc.description.sponsorship This research was supported by Explora Ciencia 2015 to M.R. (AEI - PSI2015-72568-EXP) and cofunded with 50% by the European Regional Development Fund under the framework of the ERFD Operative Programme for Catalunya 2014-2020, with a grant of 1.527.637,88€. J.C. is supported by the Spanish Ministry of Science and Innovation under the PhD fellowship BES-2017-080364. M.R is supported by European Commission Individual Fellowship (Ctrl Code – 794649, H2020-MSCA-IF-2017). G.D. is supported by the ERC Advanced Grant DYSTRUCTURE (295129), the Spanish Research Project PSI2016-75688-P, and the European Union’s Horizon 2020 Framework Programme for Research and Innovation under the Specific Grant Agreement No. 785907 (Human Brain Project SGA2). S.S.F. is supported by the Ministerio de Ciencia e Innovación (PID2019-108531GB-I00 AEI/FEDER), and AGAUR Generalitat de Catalunya (2017 SGR 1545).
  • dc.format.mimetype application/pdf
  • dc.identifier.citation Cruzat J, Torralba M, Ruzzoli M, Fernández A, Deco G, Soto-Faraco S. The Phase of Theta oscillations modulates successful memory formation at encoding. Neuropsychologia. 2021;154:107775. DOI: 10.1016/j.neuropsychologia.2021.107775
  • dc.identifier.doi http://dx.doi.org/10.1016/j.neuropsychologia.2021.107775
  • dc.identifier.issn 0028-3932
  • dc.identifier.uri http://hdl.handle.net/10230/47368
  • dc.language.iso eng
  • dc.publisher Elsevier
  • dc.relation.ispartof Neuropsychologia. 2021;154:107775
  • dc.relation.projectID info:eu-repo/grantAgreement/EC/H2020/794649
  • dc.relation.projectID info:eu-repo/grantAgreement/EC/FP7/295129
  • dc.relation.projectID info:eu-repo/grantAgreement/EC/H2020/785907
  • dc.relation.projectID info:eu-repo/grantAgreement/ES/1PE/PSI2015-72568-EXP
  • dc.relation.projectID info:eu-repo/grantAgreement/ES/1PE/PSI2016-75688-P
  • dc.relation.projectID info:eu-repo/grantAgreement/ES/2PE/PID2019-108531GB-I00
  • dc.rights © Elsevier http://dx.doi.org/10.1016/j.neuropsychologia.2021.107775
  • dc.rights.accessRights info:eu-repo/semantics/openAccess
  • dc.subject.keyword Episodic memory
  • dc.subject.keyword Ongoing oscillations
  • dc.subject.keyword Phase resetting
  • dc.subject.keyword Phase
  • dc.subject.keyword Theta
  • dc.subject.keyword Alpha
  • dc.title The Phase of Theta oscillations modulates successful memory formation at encoding
  • dc.type info:eu-repo/semantics/article
  • dc.type.version info:eu-repo/semantics/acceptedVersion

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