Characteristics of pulsed electric field cardiac ablation porcine treatment zones with a focal catheter
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- dc.contributor.author Verma, Atul
- dc.contributor.author Neal, Robert
- dc.contributor.author Evans, John
- dc.contributor.author Castellví, Quim
- dc.contributor.author Vachani, Armaan
- dc.contributor.author Deneke, Thomas
- dc.contributor.author Nakagawa, Hiroshi
- dc.date.accessioned 2025-04-28T06:25:14Z
- dc.date.available 2025-04-28T06:25:14Z
- dc.date.issued 2023
- dc.description.abstract Objectives. Pulsed electric field (PEF) therapies employ punctuated energy delivery to kill cells in a volume of tissue through mechanisms that are not dependent on thermal processes. A key component to successful cardiac ablation procedures is ensuring the generation of transmural, contiguous ablation zones, which requires in-depth knowledge regarding treatment sizes for a given therapeutic application. Methods. In this study, a series of acute treatments were delivered to porcine ventricles, where triphenyl tetrazolium chloride (TTC) vitality stain was used to identify treatment effect sizes for the three focal monopolar CENTAURI PEF cardiac ablation energy settings. Results. Treatment depths were 5.7, 7.2, and 8.2 mm for the 19, 22, and 25 A energy settings, respectively. Gross pathology indicated umbral zones of hemorrhage surrounded by pale avital TTC-negative-negative tissue, which contrasted significantly from radiofrequency ablation (RF) controls. Histologically, treatment zones are identified by regions of contraction band necrosis and cardiomyocytolysis, which contrasted with RF control lesions composed primarily of coagulation necrosis. Conclusions. Together, these data indicate the ability for focal monopolar PEF treatments to generate deep treatment zones in cardiac ablation without incurring the gross or histological coagulative characteristics of RF thermal lesions.en
- dc.format.mimetype application/pdf
- dc.identifier.citation Verma A, Neal R, Evans J, Castellvi Q, Vachani A, Deneke T, et al. Characteristics of pulsed electric field cardiac ablation porcine treatment zones with a focal catheter. J Cardiovasc Electrophysiol. 2023 Jan;34(1):99-107. DOI: 10.1111/jce.15734
- dc.identifier.doi http://dx.doi.org/10.1111/jce.15734
- dc.identifier.issn 1045-3873
- dc.identifier.uri http://hdl.handle.net/10230/70222
- dc.language.iso eng
- dc.publisher Wiley
- dc.relation.ispartof Journal of Cardiovascular Electrophysiology. 2023 Jan;34(1):99-107
- dc.rights © 2022 The Authors. Journal of Cardiovascular Electrophysiology published by Wiley Periodicals LLC. This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.
- dc.rights.accessRights info:eu-repo/semantics/openAccess
- dc.rights.uri http://creativecommons.org/licenses/by-nc-nd/4.0/
- dc.subject.keyword Aliyaen
- dc.subject.keyword CENTAURIen
- dc.subject.keyword Doseen
- dc.subject.keyword Electroporationen
- dc.subject.keyword Lesionen
- dc.subject.keyword Sizeen
- dc.title Characteristics of pulsed electric field cardiac ablation porcine treatment zones with a focal catheteren
- dc.type info:eu-repo/semantics/article
- dc.type.version info:eu-repo/semantics/publishedVersion