Functional network antagonism and consciousness

Mostra el registre complet Registre parcial de l'ítem

• dc.contributor.author Demertzi, Athena
• dc.contributor.author Kucyi, Aaron
• dc.contributor.author Ponce-Alvarez, Adrián
• dc.contributor.author Keliris, Georgios A.
• dc.contributor.author Whitfield-Gabrieli, Susan
• dc.contributor.author Deco, Gustavo
• dc.date.accessioned 2023-02-15T07:24:26Z
• dc.date.available 2023-02-15T07:24:26Z
• dc.date.issued 2022
• dc.description.abstract Spontaneous brain activity changes across states of consciousness. A particular consciousness-mediated configuration is the anticorrelations between the default mode network and other brain regions. What this antagonistic organization implies about consciousness to date remains inconclusive. In this Perspective Article, we propose that anticorrelations are the physiological expression of the concept of segregation, namely the brain’s capacity to show selectivity in the way areas will be functionally connected. We postulate that this effect is mediated by the process of neural inhibition, by regulating global and local inhibitory activity. While recognizing that this effect can also result from other mechanisms, neural inhibition helps the understanding of how network metastability is affected after disrupting local and global neural balance. In combination with relevant theories of consciousness, we suggest that anticorrelations are a physiological prior that can work as a marker of preserved consciousness. We predict that if the brain is not in a state to host anticorrelations, then most likely the individual does not entertain subjective experience. We believe that this link between anticorrelations and the underlying physiology will help not only to comprehend how consciousness happens, but also conceptualize effective interventions for treating consciousness disorders in which anticorrelations seem particularly affected.
• dc.format.mimetype application/pdf
• dc.identifier.citation Demertzi A, Kucyi A, Ponce-Alvarez A, Keliris GA, Whitfield-Gabrieli S, Deco G. Functional network antagonism and consciousness. Netw Neurosci. 2022;6(4):998–1009. DOI: 10.1162/netn_a_00244
• dc.identifier.doi http://dx.doi.org/10.1162/netn_a_00244
• dc.identifier.issn 2472-1751
• dc.identifier.uri http://hdl.handle.net/10230/55775
• dc.language.iso eng
• dc.publisher MIT Press
• dc.relation.ispartof Network Neuroscience. 2022;6(4):998–1009.
• dc.rights © MIT Press (Publisher version at http://mitpress.mit.edu). Published under a Creative Commons Attribution 4.0 International (CC BY 4.0) license.
• dc.rights.accessRights info:eu-repo/semantics/openAccess
• dc.rights.uri http://creativecommons.org/licenses/by/4.0/
• dc.subject.keyword Anticorrelations
• dc.subject.keyword Integration
• dc.subject.keyword Segregation
• dc.subject.keyword Consciousness
• dc.subject.keyword Neural inhibition
• dc.subject.keyword Functional connectivity
• dc.title Functional network antagonism and consciousness
• dc.type info:eu-repo/semantics/article
• dc.type.version info:eu-repo/semantics/publishedVersion