Neural plasticity in human brain connectivity: the effects of long term deep brain stimulation of the subthalamic nucleus in Parkinson's disease

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  • dc.contributor.author Van Hartevelt, Tim J.ca
  • dc.contributor.author Cabral, Joanaca
  • dc.contributor.author Deco, Gustavoca
  • dc.contributor.author Møller, Arneca
  • dc.contributor.author Green, Alex L.ca
  • dc.contributor.author Aziz, Tipu Z.ca
  • dc.contributor.author Kringelbach, Morten L.ca
  • dc.date.accessioned 2015-01-26T10:04:06Z
  • dc.date.available 2015-01-26T10:04:06Z
  • dc.date.issued 2014ca
  • dc.description.abstract Background: Positive clinical outcomes are now well established for deep brain stimulation, but little is known about the effects of long-term deep brain stimulation on brain structural and functional connectivity. Here, we used the rare opportunity to acquire pre- and postoperative diffusion tensor imaging in a patient undergoing deep brain stimulation in bilateral subthalamic nuclei for Parkinson’s Disease. This allowed us to analyse the differences in structural connectivity before and after deep brain stimulation. Further, a computational model of spontaneous brain activity was used to estimate the changes in functional connectivity arising from the specific changes in structural connectivity./nResults: We found significant localised structural changes as a result of long-term deep brain stimulation. These changes were found in sensory-motor, prefrontal/limbic, and olfactory brain regions which are known to be affected in Parkinson’s Disease. The nature of these changes was an increase of nodal efficiency in most areas and a decrease of nodal efficiency in the precentral sensory-motor area. Importantly, the computational model clearly shows the impact of deep brain stimulation-induced structural alterations on functional brain changes, which is to shift the neural dynamics back towards a healthy regime. The results demonstrate that deep brain stimulation in Parkinson’s Disease leads to a topological reorganisation towards healthy bifurcation of the functional networks measured in controls, which suggests a potential neural mechanism for the alleviation of symptoms./nConclusions: The findings suggest that long-term deep brain stimulation has not only restorative effects on the structural connectivity, but also affects the functional connectivity at a global level. Overall, our results support causal changes in human neural plasticity after long-term deep brain stimulation and may help to identify the underlying mechanisms of deep brain stimulation.en
  • dc.description.sponsorship MLK and TJVH are funded by the TrygFonden Charitable Foundation. TZA is funded by the Medical Research Council, the Norman Collisson Foundation/nand the Charles Wolfson Charitable Trust. ALG is supported by the NIHR Biomedical Research Centre, Oxford. GD and JC were supported by the ERC Advanced/nGrant: DYSTRUCTURE (n. 295129), by the Spanish Research Project SAF2010-16085 and by the CONSOLIDER-INGENIO 2010 Programme CSD2007-00012, the FP7-/nICT BrainScales and by the Brain Network Recovery Group through the James S. McDonnell Foundation.en
  • dc.format.extent 13 p.
  • dc.format.mimetype application/pdfca
  • dc.identifier.citation Van Hartevelt TJ, Cabral J, Deco G, Møller A, Green AL, Aziz TZ, Kringelbach ML. Neural plasticity in human brain connectivity: the effects of long term deep brain stimulation of the subthalamic nucleus in parkinson’s disease. PLoS ONE. 2014;9(1):e86496. DOI: 10.1371/journal.pone.0086496ca
  • dc.identifier.doi http://dx.doi.org/10.1371/journal.pone.0086496
  • dc.identifier.issn 1932-6203ca
  • dc.identifier.uri http://hdl.handle.net/10230/23068
  • dc.language.iso engca
  • dc.publisher Public Library of Science (PLoS)ca
  • dc.relation.ispartof PLoS ONE. 2014;9(1):e86496
  • dc.relation.projectID info:eu-repo/grantAgreement/EC/FP7/295129ca
  • dc.relation.projectID info:eu-repo/grantAgreement/EC/FP7/269921
  • dc.relation.projectID info:eu-repo/grantAgreement/ES/3PN/SAF2010-16085
  • dc.relation.projectID info:eu-repo/grantAgreement/ES/2PN/CSD2007-00012
  • dc.rights © 2014 van Hartevelt et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.(http://creativecommons.org/licenses/by/4.0/)ca
  • dc.rights.accessRights info:eu-repo/semantics/openAccessca
  • dc.rights.uri http://creativecommons.org/licenses/by/4.0/
  • dc.title Neural plasticity in human brain connectivity: the effects of long term deep brain stimulation of the subthalamic nucleus in Parkinson's diseaseca
  • dc.type info:eu-repo/semantics/articleca
  • dc.type.version info:eu-repo/semantics/publishedVersionca

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