Examining the cooperativity mode of antibody and CD8 + T cell immune responses for vaccinology
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- dc.contributor.author Bocharov, Gennady A.
- dc.contributor.author Grebennikov, Dmitry
- dc.contributor.author Argilaguet Marqués, Jordi, 1977-
- dc.contributor.author Meyerhans, Andreas
- dc.date.accessioned 2022-03-17T10:05:22Z
- dc.date.issued 2021
- dc.description.abstract A fundamental unsolved issue in vaccine design is how neutralizing antibodies and cytotoxic CD8+ T cells cooperate numerically in controlling virus infections. We hypothesize on a viewpoint for the multiplicative cooperativity between neutralizing antibodies and CD8+ T cells and propose how this might be exploited for improving vaccine-induced protective immunity.
- dc.description.sponsorship The authors are supported by the Russian Science Foundation (RSF grant no. 18-11-00171), the Russian Foundation of Basic Research (RFBR grant no. 20-04-60157), the Moscow Center for Fundamental and Applied Mathematics at INM RAS (agreement with the Ministry of Education and Science of the Russian Federation No. 075-15-2019-1624), the Spanish Ministry of Science and Innovation grant no. PID2019-106323RB-I00 (AEI/MINEICO/FEDER, UE), and “Unidad de Excelencia María de Maeztu”, funded by the AEI (CEX2018-000792-M)
- dc.format.mimetype application/pdf
- dc.identifier.citation Bocharov G, Grebennikov D, Argilaguet J, Meyerhans A. Examining the cooperativity mode of antibody and CD8 + T cell immune responses for vaccinology. Trends Immunol. 2021 Oct;42(10):852-855. DOI: 10.1016/j.it.2021.08.003
- dc.identifier.doi http://dx.doi.org/10.1016/j.it.2021.08.003
- dc.identifier.issn 1471-4906
- dc.identifier.uri http://hdl.handle.net/10230/52707
- dc.language.iso eng
- dc.publisher Elsevier
- dc.rights © Elsevier http://dx.doi.org/10.1016/j.it.2021.08.003
- dc.rights.accessRights info:eu-repo/semantics/openAccess
- dc.subject.other Vacunació
- dc.subject.other Virosis
- dc.subject.other Immunitat
- dc.title Examining the cooperativity mode of antibody and CD8 + T cell immune responses for vaccinology
- dc.type info:eu-repo/semantics/article
- dc.type.version info:eu-repo/semantics/acceptedVersion